Issue 1 Volume 14 (2023)

Computational medicine has emerged due to the advances in medical technology in parallel with big data and artificial intelligence. A new way of treating complex diseases is evolving called ‘Precision Medicine’ fueled by big data extracting meaningful information from individual variability. At the forefront is biomedical research aiming to promote the area of precision medicine. Though traditional machine learning methods have built successful models for cancer diagnosis to sars-cov

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The K.A. Timiryazev State Biology Museum has passed a hundred-year historical path. Its history is largely a reflection of Russia`s biological development in the twentieth century. Therefore, the museum`s main tasks are a complete and holistic view of biology as a science of life in all its manifestations; the dominance of the human worldview, which makes it possible to reveal and generalize the most important ideas in biology; highly scientific standards of excursions and lectures, combined wit

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The infection of the Burkholderia pseudomallei causes the disease melioidosis. for which the treatment method takes longer time, and sometimes it is difficult to completely eradicate the bacteria from the body. Moreover, its antibiotic resistance in nature created great concern in recent times. Hence, there is an urgent requirement to identify new drug molecules that can improve the current process of treatments and reduce the risk to people. This study analyzed the pyrimidine metabolic pathways

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Assessment of the state of bone tissue during biopsy examination of the material of patients with degenerative or traumatic diseases is a very urgent task of modern medicine. Such an assessment makes it possible to characterize the regenerative processes at the site of the bone defect and to choose the most effective treatment strategies. Currently, in the study of bone tissue, methods of X-ray examination and survey histological staining are used. Such methods do not allow a highly sensitive an

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For the past decade, Zimbabwe has been producing approximately a quarter of soya beans per year against national demand for food, animal feed, and industrial consumption. The gap between production and demand is met by imports from Malawi, South Africa, and Zambia. This study focuses on the larvae of Tenebrio molitor, commonly known as mealworms, as a sustainable alternative source of protein for animal feed. Conditions for breeding the mealworms in Zimbabwe were investigated and includes the co

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The progression of aging affects various blood parameters, which can weaken the viability of the body. Clarification of various aspects of this process requires additional observations, especially with the use of animals. The study was conducted on 43 healthy outbred male rats aged 24 months. Also, 32 healthy outbred male rats 3 months old, which formed the control group, were taken under observation. The examined 24-month-old rats showed standard aging phenomena. In their erythrocytes, there wa

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Platinum preparations are widely used in the treatment of cancer patients, as they have an antitumor effect. However, the use of such drugs is limited due to their high toxicity. In this study, the goal was to reveal the anticancer activity of a new complex synthesized compound based on palladium and mexidol (2-ethyl-6-methyl-3-hydroxypyridine ammonium tetrachloropalladic acid), which has low toxicity. The interaction of palladium metal complexes with EGFR kinase protein (PDB ID: 2ITO) and their

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We studied the material collected from agricultural land. Four Ascomycota fungi were isolated from the soil sample. The preliminary identification based on morphological characters using taxonomic keys was done only up to the genus level, due to overlapping characters, making identification difficult. Therefore the Internal transcribed spacer (ITS) region also called as fungal DNA barcode was sequenced. The obtained results were compared with GenBank, the NCBI database, and identification was ma

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All aging rats included in the study had standard signs of aging. As a result of regular physical activity during 60 days of observation, the existing manifestations of aging weakened in these rats. Initially, in aging rats, the processes of lipid peroxidation in erythrocytes were enhanced due to a decrease in the activity of erythrocyte antioxidant protection. Against the background of increased physical activity in the structures of erythrocytes of aging rats, the amount of lipid peroxidation

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In modern society, men often have arterial hypertension at the beginning of adulthood, which can progress rapidly and be complicated by thrombosis. It becomes necessary to improve the process of physical rehabilitation of hypertensive men of mature age. For this purpose, in men diagnosed with arterial hypertension, various schemes of systematic muscle activity are used. As a variant of the general recovery of this category of patients, a complex of physical training was developed and tested. Its

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Arterial hypertension is becoming increasingly common among diseases of the cardiovascular system. The work aimed to analyze blood pressure control in patients diagnosed with arterial hypertension. Fifty physicians and 1020 patients (under 56 years of age) participated in the study. Regular use of medications was observed in 92% of the patients, and the systolic blood pressure level was 167 mm Hg. More frequent use of renin-angiotensin system blockers compared with diuretics and calcium antagoni

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Evidence suggests that metformin, an antidiabetic drug, possesses antitumor effects in breast cancer. Although metformin is known to induce metabolic reprogramming, a detailed description of the metabolites altered by metformin in breast cancer cells is limited. In this study, we aimed to investigate metformin’s anti-tumor effect on breast cancer cell lines and to conduct an untargeted metabolic analysis in those cell lines post-metformin treatment. Metformin’s effect on cell viabili

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A growing number of research on management and diagnostic strategies in respiratory distress syndrome have been undertaken; nevertheless, there is no clear consensus on the prognosis among those patients. The goal of this systematic review was to consolidate current data on the management and diagnosis of patients with respiratory distress syndrome. The authors began by recognizing the important examination proof that spots light on the management and diagnosis of respiratory distress syndrome.

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