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2023 Volume 14 Issue 1

Physiological Features of Erythrocytes in the Aging Organism


Elena Sergeevna Tkacheva, Ilya Nikolaevich Medvedev, Nadezhda Viktorovna Vorobyeva, Valerii Panteleevich Kartashev, Galina Sergeevna Mal
Abstract

The progression of aging affects various blood parameters, which can weaken the viability of the body. Clarification of various aspects of this process requires additional observations, especially with the use of animals. The study was conducted on 43 healthy outbred male rats aged 24 months. Also, 32 healthy outbred male rats 3 months old, which formed the control group, were taken under observation. The examined 24-month-old rats showed standard aging phenomena. In their erythrocytes, there was an increase in lipid peroxidation caused by a weakening of the activity of their antioxidant defense. In the blood of two-year-old rats, there was a decrease in the level of erythrocyte-discocytes. This was accompanied in them by an excess content of erythrocytes in the blood, which had a changed shape to varying degrees. In rats of the older group, erythrocyte aggregation was increased, as indicated by an increase in the numberof erythrocytes that entered the aggregates in the blood and an increase in the number of most erythrocyte aggregates with a decrease in the level of free erythrocytes. For two-year-old rats, low content of erythrocytes-disconcytes in the blood and an excess number of erythrocytes with a modified shape, as well as an increase in their aggregation, are characteristics. An important reason for these changes is the weakening of the antioxidant protection of erythrocytes, leading to a pronounced activation of lipid peroxidation in them.


How to cite this article
Vancouver
Tkacheva ES, Medvedev IN, Vorobyeva NV, Kartashev VP, Mal GS. Physiological Features of Erythrocytes in the Aging Organism. J Biochem Technol. 2023;14(1):34-9. https://doi.org/10.51847/qvv0KOI1e4
APA
Tkacheva, E. S., Medvedev, I. N., Vorobyeva, N. V., Kartashev, V. P., & Mal, G. S. (2023). Physiological Features of Erythrocytes in the Aging Organism. Journal of Biochemical Technology, 14(1), 34-39. https://doi.org/10.51847/qvv0KOI1e4
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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative