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2023 Volume 14 Issue 1

Mathematical Modeling of the Biological Activity of a New Complex Compound Based on Palladium and Mexidol


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Abstract

Platinum preparations are widely used in the treatment of cancer patients, as they have an antitumor effect. However, the use of such drugs is limited due to their high toxicity. In this study, the goal was to reveal the anticancer activity of a new complex synthesized compound based on palladium and mexidol (2-ethyl-6-methyl-3-hydroxypyridine ammonium tetrachloropalladic acid), which has low toxicity. The interaction of palladium metal complexes with EGFR kinase protein (PDB ID: 2ITO) and their activity against these proteins were investigated. First, the palladium metal complex and protein have interacted with the HEX program. Afterward, PLIP analysis was performed to examine the interaction of metal complexes with protein in detail. Afterward, a Swiss ADME/T analysis of this palladium complex was performed. According to the Hodge and Sterner toxicity scale, the studied compound belongs to the group of moderately toxic substances that are allowed in medicine. As a result of the conducted calculations, the authors commented on the activity of the Pd metal complex. The interaction of the pd metal complex with the EFGR kinase protein was examined by PLIP analysis and its movements in human metabolism were predicted by ADME analysis of the Pd metal complex.


How to cite this article
Vancouver
Tüzün B, Jafarova R, Bagirov I, Magerramova N, Nasibova T. Mathematical Modeling of the Biological Activity of a New Complex Compound Based on Palladium and Mexidol. J Biochem Technol. 2023;14(1):40-4. https://doi.org/10.51847/ksxuz54Cjf
APA
Tüzün, B., Jafarova, R., Bagirov, I., Magerramova, N., & Nasibova, T. (2023). Mathematical Modeling of the Biological Activity of a New Complex Compound Based on Palladium and Mexidol. Journal of Biochemical Technology, 14(1), 40-44. https://doi.org/10.51847/ksxuz54Cjf
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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a double-blind peer reviewed International Journal published by the Deniz Publication on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

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FOCUS AND SCOPE
Journal Of Biochemical Technology Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative