Written by Zoubir Kebaili
Published On Issue 1 Vol 10, 2019
Medicinal plants are considered as a very important source of secondary metabolites and therefore bioactive molecules. Our comparative study deals with two species: Hyoscyamus albus and Hyoscyamus muticus harvested in two different climate regions namely: Arris (semi-arid, wilaya of Batna) and Djanet (arid, wilaya of Illizi), respectively. The phytochemical screening revealed that aerial parts of the two species contain almost all classes of secondary metabolites such as flavonoids, quinones, an
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Written by Gunasekar Manoharan
Published On Issue 1 Vol 10, 2019
A simple and gradient RP- HPLC method has been validated and developed for Entecavir in bulk and tablet dosage form. The proposed method was validated to obtain official requirements including stability, accuracy, precision, linearity and selectivity. The method was developed on C18 column (250 x 4.6 mm ID) using the mobile phase composition as methanol: water (55:45 v/v). The flow rate was set as 1ml/minute and the maximum absorption was observed at 254 nm. The Entecavir drug showed a precise a
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Written by Maryam Sohrabi
Published On Issue 1 Vol 10, 2019
Introduction: Commercial high-fructose corn syrup is factor of obesity, implicated in interactions with oxidative stress and turmeric as an anti-oxidant could attenuate effects of it. The aim of study was to investigate the effects of turmeric on testicular SLC2A5 expression in rats fed on commercial 15% high-fructose corn syrup. Materials and Methods: Forty Wistar albino rats were divided into five groups (A, B, C, D and E each: n=8). All were feeding with standard diet in addition to solutions
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Written by Nadia N. Osman
Published On Issue 1 Vol 10, 2019
Introduction: Among the most prevalent psychiatric turmoils and the problems in human life, exhibit depression. Women are suffering from depression overmuch predominately than men and frequently cluster in the childbearing years. For women with pre-existing psychiatric ailments, Gestation and postnatal periods are large hazard times comparatively. This work designed to explore potential relation between depression and the fluctuation in the level of hormones and neurotransmitters. Methods: In th
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Written by Regadia Aissaoui
Published On Issue 1 Vol 10, 2019
1, 2 Polyfunctionalized benzene derivatives have been important structural units present in certain molecules used in a wide range of applications (pharmaceutical, biological, cosmetic, etc.). In this work, the synthesis of 1 and 2 polyfunctionalized benzene derivatives has been proceeded from largely available and cheap reagents namely: β-keto-ester salicylic aldehydes and alkyl halides. The inspiring obtained results emphasized on the interesting strategy implemented for the synthesis of
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Written by Gunasekar Manoharan
Published On Issue 1 Vol 10, 2019
The main aim of this study was to investigate the performance of development method for methylparaben and butylparaben determination in skin ointment product by High Performance Liquid Chromatography (HPLC). The method validation parameters were evaluated as per International Conference on Harmonisation (ICH) Guidelines. The method shows the specificity has retention time of methylparaben and butylparaben at 2.10 minutes and 6.64 minutes, respectively. The mobile phase had acetonitrile, methanol
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Written by Hamzeh Salehzadeh
Published On Issue 1 Vol 10, 2019
The goal of this study was to determine the blood lead concentration in various occupational workers in Sanandaj and its effects on oxidative stress parameters and other blood parameters. This descriptive-analytic study was carried out in Sanandaj, Iran. A total of 278 subjects were selected as the sample size for this study, of which 64 did not have exposure to theoccupational lead, and 214 had the occupational exposure tolead. The blood lead levels were measured by the atomic absorption spectr
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Written by Anbrah A. Alzubidi
Published On Issue 1 Vol 10, 2019
Background- Migraine is a common neurological disorder. It affects 11% of the world's population and 2.6-5 % of the Saudi population. Its prevalence in women is 3 times more than in men. Although the pathogenesis of migraine headache is not fully understood but there is an assumption that some nutrients may be related to headache. This study was designed to measure the levels of vitamin D, calcium, sodium, and potassium that might have a relationship with migraine in Saudi females. Methods-
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Written by Elsayed M. AbouElleef and Saleh D. Mekkey
Published On Issue 1 Vol 10, 2019
The association parameters of both bulk and nano-CuSO₄ salts in (EtOH-H₂O) mixed solvents were estimated at room temperature (293.15K) using conductivity method by applying Fuoss-Shedlovsky calculation. The association parameters of nano-CuSO4 was greater than bulk CuSO₄ salt. The interaction between the cation (Cu²+) with ligand (ciprofloxacin, CFL) in (EtOH-H₂O) mixed solvents at room temperature (293.15K) was determined by the conduct metric method. The formation Gibbs free energies chan
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Written by Shouq A. Alshehri
Published On Issue 1 Vol 10, 2019
Migraine is a common disabling primary headache disorder. It affects 6% of men and 18% of women worldwide and 12.1% in Saudi Arabia. The lack of many nutrients like vitamin B12 and magnesium is associated with migraine. Migraine may be socicated with cardiovascular risk factors such as a high level of cholesterol. Ninety-one Saudi female patients with a mean age of 32.91±1.187 and fifty-four healthy Saudi females (control) with a mean age of 30.00±1.32 years participated in this st
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Written by Najlaa Hassan Halawi
Published On Issue 1 Vol 10, 2019
Doxorubicin (Dox) is the most potent antitumor of wide spectrum. It is used only by developing cardiomyopathy threatening life. Cardiomyopathy is a disease of the heart muscle, categorized by abnormal wall thickness, chamber size and other functional contractile abnormalities. Pycnogenol (PYC) is an aqueous extract of the pine bark known for its content of bioactive flavonoids. The study aimed to examine the cardio-protective and therapeutic efficacy of Pycnogenol on doxorubicin brought cardiomy
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Written by Elham M. Hussien
Published On Issue 1 Vol 10, 2019
Throughout the years, azo compounds including Sudan dyes have been widely used in industry as colorants in food, cosmetics, waxes, solvents, textiles, plastics and printing inks. Sudan dyes I, II, III, IV, and their degradation products have been regarded to hurt human health. They cause cancer due to their teratogenicity, genotoxicity and carcinogenicity effects. In the present work, the efficiency of ferrous sulfate with low cost and the first choice in the treatment of printing, dyeing and el
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Written by Latifa Kribaa
Published On Issue 1 Vol 10, 2019
Four new azo-azomethine ligands (b2, b3, c2 and c3) have been prepared from the reaction of 4, 4′ (diamino diphenyl) methane with 5-(4-X-phenyl)-azo-salicylaldehyde (X = H, CH3 and Br). Furthermore, derivatives of Schiff bases (c1–3) have been prepared by the reduction of imine function (b1–3) with Sodium borohydride. The dyes have been characterized by IR, UV–Vis and 1H NMR spectroscopic techniques as well as elemental analysis. In addition, the assessment of the antioxi
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Written by Ohoud Abdullah Albeladi
Published On Issue 1 Vol 10, 2019
Kidney diseases are common health problems around the world and have different causes. Therefore, the study was based on glycerol because it is used extensively to determine the extent of the effect on the kidneys. Gum Arabic was chosen as a preventive treatment to reduce inflammation. The experiment was carried out on 70 male Albino rat, with a weight of 200-250 g. To verify kidney efficiency, pyramphenol blue dye was used to detect the level of proteins in the kidney. Also, a shif detector was
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