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2019 Volume 10 Issue 1

The Correlation between Migraine and Some Associated Bio-markers in Saudi Females


Anbrah A. Alzubidi, Foziah A. Alshubaily, Shuog A. Alshehri, Hala S. Sonbol, Sawsan A. Rahimuddin, Ebtihaj J. Jambi
Abstract

Background- Migraine is a common neurological disorder. It affects 11% of the world's population and 2.6-5 % of the Saudi population. Its prevalence in women is 3 times more than in men. Although the pathogenesis of migraine headache is not fully understood but there is an assumption that some nutrients may be related to headache. This study was designed to measure the levels of vitamin D, calcium, sodium, and potassium that might have a relationship with migraine in Saudi females. Methods- The sample comprised 91 previously diagnosed migraine patients and 54 healthy control subjects. We collected data regarding age, weight, height, marital status, education, medical history, and consumption of vitamin and mineral supplements for each participant. Blood sample was obtained, and serum vitamin D, calcium, sodium and potassium were measured at the chemistry lab in King Abdulaziz Hospital. For between group comparisons independent-sample t-test analysis of variance was done. Results- There were 91 migraine patients aged (mean ± SEM) 32.91 ± 1.187 years and 54 controls aged (mean ± SEM) 30.00 ± 1.320 years. No significant differences were found in migraine patients compared with the healthy controls in vitamin D, sodium and potassium concentrations (p>0.05). However, we found a significant difference in calcium serum level between the two groups (p= 0.00002). Conclusion- A higher significant difference in calcium level in migraine patients was observed compared to the healthy controls, while no significant differences were observed in the other parameters. Future studies should attempt to confirm the relationship between calcium deficiency and migraine. In addition, there is a need for well-designed clinical trials to investigate the effects of serum vitamin D, calcium, sodium and potassium serum levels on higher risk of migraine.


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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative