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2019 Volume 10 Issue 1

Study of the Effect of Sudan II and Treatment water Coupled with Fe²+ in Modulating Hematological and Biochemical Changes in Rabbits’


Elham M. Hussien, Sawsan M. Abu El Hassan and Ferial M.N. Fudllalah
Abstract

Throughout the years, azo compounds including Sudan dyes have been widely used in industry as colorants in food, cosmetics, waxes, solvents, textiles, plastics and printing inks. Sudan dyes I, II, III, IV, and their degradation products have been regarded to hurt human health. They cause cancer due to their teratogenicity, genotoxicity and carcinogenicity effects. In the present work, the efficiency of ferrous sulfate with low cost and the first choice in the treatment of printing, dyeing and electroplating wastewater to reduce the toxicity of Sudan II-induced oxidative damage to hematological parameters, liver and kidney functions in adult female and male rabbits was investigated. Animals which received Sudan II were treated with ferrous sulfate as the sole source of potent liquid for 14 days at the dose of 111mg/kg B.wt before being sacrificed. Hematological parameters (total leukocytes (WRBs), erythrocytes (RBCs) count hemoglobin content (Hb) and hematocrit percentage (Ht%), liver and kidney functions were done to check the efficiency of ferrous sulfate as Sudan II detoxification. The obtained data clearly showed that Sudan II toxicity led to a significant reduction in (WBCs, RBCs, Hb, and Ht) of the hematological parameters. Sudan II led to an elevation in the activity of liver function enzymes (transaminase; ALT and AST), a decrease in Alkaline phosphatase ALP and an increase in kidney functions (urea and creatinine). The detoxification properties of ferrous sulfate were obvious thanks to good flocculation and decolorization, utilized to separate heavy metal ions, oils, phosphorus and forpurification, and wastewater. Finally, the present study proved that Sudan II treated with ferrous sulfate can keep hematological parameters, liver and kidney functions near the physiological normal state.


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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative