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2019 Volume 10 Issue 1

The Effects of Curcuma Longa L. on Testicular SLC2A5 Expression and Sperm Parameters in Rat with High Fructose Corn Syrup Diet


Maryam Sohrabi, Saadat Torabian
Abstract

Introduction: Commercial high-fructose corn syrup is factor of obesity, implicated in interactions with oxidative stress and turmeric as an anti-oxidant could attenuate effects of it. The aim of study was to investigate the effects of turmeric on testicular SLC2A5 expression in rats fed on commercial 15% high-fructose corn syrup. Materials and Methods: Forty Wistar albino rats were divided into five groups (A, B, C, D and E each: n=8). All were feeding with standard diet in addition to solutions consisting of just water (A or Control), water solution plus high fructose corn syrup(B), water solution plus turmeric (C), water solution plus mixed high fructose corn syrup + low turmeric solution(D) or high cinammon(E). The testicular SLC2A5 expression studied by immunohistochemical method. Sperms were obtained from the tail of epididymis and their quality parameters (count, vitality, motility and morphology) were analyzed. Results: Number of positive SLC2A5 cells decreased in the C and increased in groups B, D and E groups compared to control (P<0.05). The body weight gain of animals increased in the B to control group (P<0.05) and adding turmeric had no significant effect. Data of sperm count and motility of sperms showed a decrease in group C compare with control group and adding turmeric extract could increased sperm count and did not has effect on normal morphology. Furthermore, there was no significant difference between sperm viability of the selected groups. Conclusion: High fructose corn syrup increased body weight gain and SLC2A5 expression in testicular tissue and turmeric had no significant effect on them


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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative