Introduction: Commercial high-fructose corn syrup is factor of obesity, implicated in interactions with oxidative stress and turmeric as an anti-oxidant could attenuate effects of it. The aim of study was to investigate the effects of turmeric on testicular SLC2A5 expression in rats fed on commercial 15% high-fructose corn syrup. Materials and Methods: Forty Wistar albino rats were divided into five groups (A, B, C, D and E each: n=8). All were feeding with standard diet in addition to solutions consisting of just water (A or Control), water solution plus high fructose corn syrup(B), water solution plus turmeric (C), water solution plus mixed high fructose corn syrup + low turmeric solution(D) or high cinammon(E). The testicular SLC2A5 expression studied by immunohistochemical method. Sperms were obtained from the tail of epididymis and their quality parameters (count, vitality, motility and morphology) were analyzed. Results: Number of positive SLC2A5 cells decreased in the C and increased in groups B, D and E groups compared to control (P<0.05). The body weight gain of animals increased in the B to control group (P<0.05) and adding turmeric had no significant effect. Data of sperm count and motility of sperms showed a decrease in group C compare with control group and adding turmeric extract could increased sperm count and did not has effect on normal morphology. Furthermore, there was no significant difference between sperm viability of the selected groups. Conclusion: High fructose corn syrup increased body weight gain and SLC2A5 expression in testicular tissue and turmeric had no significant effect on them
