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2019 Volume 10 Issue 1

Study of the Thermodynamic Parameters for Interaction of Ciprofloxacin Antibiotic with Bulk and Nanocopper Sulfate


Elsayed M. AbouElleef and Saleh D. Mekkey
Abstract

The association parameters of both bulk and nano-CuSO₄ salts in (EtOH-H₂O) mixed solvents were estimated at room temperature (293.15K) using conductivity method by applying Fuoss-Shedlovsky calculation. The association parameters of nano-CuSO4 was greater than bulk CuSO₄ salt. The interaction between the cation (Cu²+) with ligand (ciprofloxacin, CFL) in (EtOH-H₂O) mixed solvents at room temperature (293.15K) was determined by the conduct metric method. The formation Gibbs free energies change (∆Gf) and transfer Gibbs free energies change (∆Gt) were increased in negative signs with increasing in EtOH content in the binary solvent. Two stoichiometric complexes 1:2 and 1:1 (M:L) are formed and the formation constant and Gibbs free energy of the formed complexes follow the order: Kf (1:1) > Kf (1:2) and ∆Gf (1:1) > ∆Gf (1:2) for (M:L) ( in negative values), which indicate more favorable formation of (1:1) complex compared with (1:2) complex. Also there are a decrease in values of Kf and ∆Gf in case of using nano-CuSO4 than that of using bulk-CuSO₄ but in small difference due to the more solvation effect in case of using nanoparticles


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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative