Kidney diseases are common health problems around the world and have different causes. Therefore, the study was based on glycerol because it is used extensively to determine the extent of the effect on the kidneys. Gum Arabic was chosen as a preventive treatment to reduce inflammation. The experiment was carried out on 70 male Albino rat, with a weight of 200-250 g. To verify kidney efficiency, pyramphenol blue dye was used to detect the level of proteins in the kidney. Also, a shif detector was used to explain the proportion of sugars in the kidney. The rats were divided into four groups; the first one was the standard (10): food and water were given only daily. The second group: treatment with glycerol for 4 weeks (20) with a dose of 10 ml / km. The third one: treated with glycerol for 8 weeks (20) at a dose of 10 ml / km. The fourth group: treatment with gum extract in the dose of 3 ml / km for 4 weeks (20). The serum was obtained to study the level of creatinine, and its increase was recorded in rats treated with glycerol and the low rate of treatment with Arabic gum. The results of the study of the kidneys in the groups treated with glycerol showed sharp changes in the cortex where there is enlargement and atrophy of some glomeruli, dissolution and dissociation in the capillaries of the capillaries and the broadening of the urinary cavity of the glomeruli. The color of the paramphenol blue and the shif is clearly shown as a result of the accumulation of proteins and sugars in the kidney. The Kidney failure and kidney dysfunction slight improvement was observed in the form of glomeruli and renal tubules, a lack of deformities in the nuclei and a decrease in hemorrhage between the tubes. The Arab gum treatment reduces the severity of kidney inflammation if used at the beginning of the discovery of inflammation.