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2019 Volume 10 Issue 1

Impact of Altered Hormonal and Neurochemical Levels on Depression Symptoms in Women During Pregnancy and Postpartum Period


Nadia N. Osman, Alaa I. Bahri
Abstract

Introduction: Among the most prevalent psychiatric turmoils and the problems in human life, exhibit depression. Women are suffering from depression overmuch predominately than men and frequently cluster in the childbearing years. For women with pre-existing psychiatric ailments, Gestation and postnatal periods are large hazard times comparatively. This work designed to explore potential relation between depression and the fluctuation in the level of hormones and neurotransmitters. Methods: In the current work, ninety-five women aged 18-40 years consented to participate. They were allocated into three groups, which were as follow: Healthy non pregnant females (1st, control group), pregnant women during the third trimester (36-39 weeks) of gestation (2nd group) women in the early (1-2 days) postpartum period (3rd, group). Using a self-report questionnaire, we surveyed all eligible women at the Maternity and Children's Hospital in Azizia in Jeddah City. Depressive symptoms were accomplished by the help of Edinburgh Postnatal Depression Scale, Arabic version during the same period. After an overnight fast, blood samples were withdrawn for inspect of hormones (estrogen, progesterone and prolactin), neurotransmitters (Dopamine, Serotonin and Norepinephrine). Results: Pregnancy and postpartum groups exhibited significant increment in estrogen, progesterone, prolactin and norepinephrine levels accompanied by significant decline in dopamine and serotonin versus control group. Conclusion: It is clear that depression in late pregnancy and postpartum associates with some psychosocial, socioeconomic, neurotransmitters and hormonal variables.


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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative