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2019 Volume 10 Issue 1

Preparation of Polyfunctioneled 1,2-Benzylated Derivatives from O-Salycilique Aldehyde and B-Ketoesters


Regadia Aissaoui, Ahmed Khalifa, Zineb Mokhtari, Aissa Benhamida, Khamiss Kussay, Noureddine Gherraf
Abstract

1, 2 Polyfunctionalized benzene derivatives have been important structural units present in certain molecules used in a wide range of applications (pharmaceutical, biological, cosmetic, etc.). In this work, the synthesis of 1 and 2 polyfunctionalized benzene derivatives has been proceeded from largely available and cheap reagents namely: β-keto-ester salicylic aldehydes and alkyl halides. The inspiring obtained results emphasized on the interesting strategy implemented for the synthesis of such molecules. The NMR spectroscopic analysis was used to identify the structure of different isolated products in the form of a single stereoisomer designed as E-configuration.

In fact, the following seven condensation products were obtained:

1-(E)-methyl 2-(3-(2-(allyloxy) phenyl) acryloyl) pent-4-enoate

2-(E)-methyl 5-(2-(allyloxy) phenyl)-3-oxo-2-(prop-2-ynyl) pent-4-enoate

3-(E)-methyl 2-(3-(2-(but-3-enyloxy) phenyl) acryloyl) pent-4-enoate

4-(E)-methyl 5-(2-(but-3-enyloxy) phenyl)-3-oxo-2-(prop-2-ynyl)pent-4-enoate

5-(E)-methyl 2-(3-(2-(pent-4-enyloxy) phenyl) acryloyl) pent-4-enoate

6-(E)-methyl 3-oxo-5-(2-(pent-4-enyloxy) phenyl)-2-(prop-2-ynyl)pent-4-enoate


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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative