2025 Volume 16 Issue 4
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Bioactive Compounds in Integrative Therapies: A Preventive and Therapeutic Approach to Autonomic Nervous System Dysfunction


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  1. Department of Biotechnology, Kemerovo State University, Kemerovo, Russia.
  2. Research and Production Association «Biolit», Tomsk, Russia.
  3. Department of Biotechnology, Kemerovo State University, Kemerovo, Russia.
  4. Department of Hygiene, Kemerovo State Medical University of the Ministry of Health of the Russian Federation, Kemerovo, Russia.
  5. Department of Management, Entrepreneurship and Engineering, Ural State University of Economics, Yekaterinburg, Russia.

  6. Department of Agronomy and Technology of Agricultural Production and Processing, Tomsk Agricultural Institute – Branch of Novosibirsk State Agrarian University, Tomsk, Russia.
Abstract

Clinical studies were conducted to evaluate the effectiveness of the developed dietary supplement, based on vegetable oil and maral antler extract, containing phospho- and glycolipids. The dietary supplement was prescribed to a group of 30 patients (main group) for 4 weeks, once before or during meals in the first half of the day, in a dosage of 10 drops. The control group of patients did not receive any dietary supplements. Based on screening diagnostics, all patients were found to have autonomic nervous system (ANS) disorders. The patients in the main group had an average of 10±2 clinical manifestations of panic attacks (PA). A reliable decrease in clinical manifestations of PA was observed in all patients taking the dietary supplement (p<0.05). A complete alleviation of manifestations such as fear of death and the feeling of inability to control oneself at any given time was observed. There was a subjective improvement in well-being, manifested by decreased emotional instability, increased vitality and performance, increased work effectiveness, and decreased complaints about PA in all patients. The additional inclusion of nutritional supplements in the diet of patients with PA resulted in a significant redistribution of adaptive response types towards a reliable increase in the number of patients with a physiological response of training and activation, and a reliable (p < 0.05) decrease in the number of patients with acute and chronic stress. Based on the studies, it was concluded that the additional inclusion of dietary supplements in the diet leads to reliable normalization of the functional state of the autonomic nervous system, increased overall performance, and adaptive responses. A positive dynamic was observed in the state of the central and autonomic nervous system. The mechanism of ANS harmonization involves a decrease in tone via the sympathetic nervous system, followed by normalization under the influence of the parasympathetic nervous system.


How to cite this article
Vancouver
Petrovich SV, Dmitrievna AD, Mikhailovich PV, Boisdzhoni T, Valerievna CY. Bioactive Compounds in Integrative Therapies: A Preventive and Therapeutic Approach to Autonomic Nervous System Dysfunction. J Biochem Technol. 2025;16(4):48-55. https://doi.org/10.51847/O5qTFrOQsj
APA
Petrovich, S. V., Dmitrievna, A. D., Mikhailovich, P. V., Boisdzhoni, T., & Valerievna, C. Y. (2025). Bioactive Compounds in Integrative Therapies: A Preventive and Therapeutic Approach to Autonomic Nervous System Dysfunction. Journal of Biochemical Technology, 16(4), 48-55. https://doi.org/10.51847/O5qTFrOQsj
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