Herpes zoster (HZ) is a viral infection that can infect humans, and causes chicken pox and/or shingles. With the emergence of HZ vaccine, this community-based survey was embarked upon to assess the knowledge and perceptions regarding the infection and its vaccine in Saudi Arabia. A cross-sectional study design and non-probability convenient sampling methods were used to recruit 939 participants that responded to the standardised closed-ended questionnaires, administered through a face-to-face interview or online survey. Pearson’s χ2 test, and logistic regression analysis were used in the data analysis at 5% significant level. Beta coefficients and 95% confidence interval (CI) were employed to present the outcomes of crude odds ratio (COR) and adjusted odds ratio (AOR). Awareness about HZ and its vaccine were 87.0% and 54.9%, respectively. The highest source of knowledge about the viral infection was internet (24.1%), with immunodeficiency identified as the most common symptom (33.5%). Awareness about HZ was more likely among participants aged 56 – 60 years (AOR=1.96; 95% CI: 1.07, 3.58), 61 – 65 years (AOR: 95% CI: 1.22, 4.40), and those in urban area (AOR=3.58; 95% CI: 2.40, 5.35). The source of knowledge regarding HZ vaccine was highest (26.2 %) with doctors. For HZ vaccine, participants who were more likely aware included those aged 50 – 55 years (AOR=1.77; 95% CI: 1.15, 2.72), Saudi citizens (AOR=1.42; 95% CI: 1.04, 1.94), and urban dwellers (AOR=1.68; 95% CI: 1.25, 2.27). This study indicates significant variations in knowledge and perceptions of the participants regarding HZ and its vaccine. There is a need for more enlightenment on the virus and its vaccine in the study area.
