Written by Arina Railievna Krasnoshchekova
Published on Issue 4 Vol 16, 2025
The purpose of this scientific work is to conduct a comparative analysis of the diagnostic effectiveness, time, and economic indicators of deep learning algorithms and expert assessment in the diagnosis of brain development abnormalities in newborns according to neuroimaging data from the UNICEF BIGH dataset. In a retrospective study, 300 ultrasound and MRI scans were used. Each case was independently analyzed by the U-Net segmentation model, the EfficientNet classification model, a group of und
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Written by Haitham Al-Madhagi
Published on Issue 4 Vol 16, 2025
The cold brain tumor glioblastoma is one of the aggressive cancers that display infiltrative cells and chemoresistance. The reference treatment with Temozolamide unveiled a significant survival rate, while the specific targeted therapy, such as monoclonal antibodies, is hindered by impermeability through the blood-brain barrier. The present study aims to utilize the pharmacology of peptide-ligand conjugates (PLC) as a preferable targeted option for such a complex type of cancer. GGKRPAR and RPAR
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Written by Thamoghna Sure
Published on Issue 4 Vol 16, 2025
The rapid global spread and impact of SARS-CoV-2 and other emerging infectious diseases highlight the urgent need for the swift development of effective vaccines. Traditional vaccine production processes are time-consuming and resource-intensive. The present study focused on an in-silico strategy combined with sophisticated bioinformatics tools to develop a multi-epitope vaccine candidate against the SARS-CoV-2 membrane glycoprotein. The full SARS-CoV-2 genome was downloaded from NCBI to determi
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Written by Anastasia Evgenievna Verstova
Published on Issue 4 Vol 16, 2025
This prospective cohort study investigates the association between metabolic disturbances and reproductive dysfunction in women with idiopathic infertility and recurrent pregnancy loss (RPL). Conducted at the Perinatal Centre of Grozny from 2022 to 2025, the study involved 240 women allocated into three groups: Group 1 (n=120) with idiopathic infertility/RPL, Group 2 (n=60) with tubal factor infertility, and a control Group 3 (n=60) of fertile women. All participants underwent a comprehensive as
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Written by Asmaa Abdulrazaq Al Sanjary
Published on Issue 4 Vol 16, 2025
The current male infertility crisis is attributed to the increasing rate of infertility; many congenital and acquired conditions have been recognized, but currently, 70 % of the causes are still unknown despite advances in andrology. Many cases are diagnosed as having unexplained infertility, while a large number are recognized as being idiopathic. A prospective cross-sectional study was held in Mosul city, Iraq, at an outpatient infertility clinic. The study includes 216 males of subfertile cou
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Written by Sergun Valeriy Petrovich
Published on Issue 4 Vol 16, 2025
Clinical studies were conducted to evaluate the effectiveness of the developed dietary supplement, based on vegetable oil and maral antler extract, containing phospho- and glycolipids. The dietary supplement was prescribed to a group of 30 patients (main group) for 4 weeks, once before or during meals in the first half of the day, in a dosage of 10 drops. The control group of patients did not receive any dietary supplements. Based on screening diagnostics, all patients were found to have autonom
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Written by Ahmed Abdulsallam
Published on Issue 4 Vol 16, 2025
Acetaminophen (AMP)-induced hepatotoxicity (AIH) is the critical side effect associated with high-dose exposure. N-acetylcysteine (NAC) is the gold standard to preserve the liver against AMP toxicity, with some drawbacks, leading to the search for alternative therapy. The antioxidant properties of methylene blue (MB), make its application plausible for AIH, as an additive therapy with NAC or alone. Therefore, the present study aimed to define the histological impact of MB on hepatoprotection. A
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