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2021 Volume 12 Issue 1

Anticuagulants: An Overview of Natural and Synthetic Therapeutic Anticoagulants


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Abstract

Any substance which prevents blood from clotting or prolongs the clotting time is called an anticoagulant. Some of them are isolated from natural sources like heparin, hirudin, anti-thrombin, urokinase, and streptokinase and some are synthetic e.g., Warfarin, acenocoumarol, brodifacoum. Several proteins with anticoagulant properties isolated from natural sources are currently employed in treating thrombotic disorders. Heparin and Warfarin are the two most widely used natural and synthetic anticoagulant drugs respectively, for the treatment of thrombotic disorders like deep vein thrombosis, acute myocardial infarction, thromboembolism, prevention of systemic embolism in patients with atrial fibrillation. This review article focuses on currently available and newer classes of natural and synthetic anticoagulants, their mechanism of action, and therapeutic potential. Pubmed databases was used for articles selection, papers on natural and synthetic anticoagulants were obtained and reviewed. This review article helps in better understanding the underlying pathways of currently available natural and synthetic anticoagulants and will be useful in designing/discovering new classes of drugs.


How to cite this article
Vancouver
Chanda C, Aluru RR. Anticuagulants: An Overview of Natural and Synthetic Therapeutic Anticoagulants. J Biochem Technol. 2021;12(1):17-21. https://doi.org/10.51847/GRccY6BTJ6
APA
Chanda, C., & Aluru, R. R. (2021). Anticuagulants: An Overview of Natural and Synthetic Therapeutic Anticoagulants. Journal of Biochemical Technology, 12(1), 17-21. https://doi.org/10.51847/GRccY6BTJ6
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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a double-blind peer reviewed International Journal published by the Deniz Publication on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative