Written by Jehan Abdulwahab Mohammad
Published on Issue 1 Vol 17, 2026
Resistin, a hormone secreted by adipose tissue and immune cells, has a key role in the diagnosis and treatment of many inflammatory and metabolic disorders. However, the precise role of resistin in the human body remains to be studied further. Sixty-seven individuals were involved in this study and divided into 2 groups: 36 patients with stage III periodontitis (case group) and 31 healthy individuals (control group). In addition to their ages, sexes, and body mass index, serum levels of resistin
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Written by Tugolbay Mamaev
Published on Issue 1 Vol 17, 2026
The transmission of viral hepatitis through hemocontact continues to be a significant public health problem because it affects numerous people at high rates throughout the world. The ongoing surveillance efforts fail to detect numerous cases of infection, which makes prevention initiatives more challenging. The study measured viral hepatitis B (HBV) and viral hepatitis C (HCV) serological marker distribution and new cases among Osh region inhabitants from 2015 through 2024. Analytical, statistic
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Written by Sarraa Dhiaa
Published on Issue 1 Vol 17, 2026
Lipophilic statins (e.g., simvastatin (SMV)) played a cytoprotective role against various injuries via mitigating neuroinflammation and attenuating oxidative damage. Doxorubicin (Dox) leads to tissue injury, particularly cardiotoxicity and brain toxicity. The present study aimed to investigate the neuroprotective potential of SMV against Dox-induced neurotoxicity in rats. A total of 56 Albino Wistar rats were housed in cages and subclassified into control male and female groups, Dox male and fem
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Written by Zalina Yuryevna Sozaeva
Published on Issue 1 Vol 17, 2026
The rising prevalence of obesity among adolescents has become a global health concern, directly contributing to the early development of cardiovascular risk. This prospective multicenter cohort study aimed to investigate the dynamics of hemodynamic mechanisms underlying the formation of arterial hypertension (AH) in this patient category during the critical period of pubertal development. The study included 498 adolescents aged 12-17 years from major cities in the North Caucasus, stratified by b
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Written by Valery Petrovich Sergun
Published on Issue 1 Vol 17, 2026
This study investigates the potential of novel biocomplexes derived from maral antlers (Pantobiol-4 formulations) to counteract cognitive impairment in a rat model of Alzheimer's disease (AD) induced by amyloid-beta 25-35 injection. Three Pantobiol preparations (Pantobiol-4-1, Pantobiol-4-2, and Pantobiol-4-3) were evaluated at different doses using behavioral (novel object recognition and passive avoidance) and biochemical [choline acetyltransferase (ChAT) activity, testosterone, and dehydr
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Written by Inas Hazem Ahmed
Published on Issue 1 Vol 17, 2026
Dracaena cinnabri is a popular medicinal plant in the peninsula of Arabia and other countries, used as an herbal cure for a variety of ailments such as astringent, analgesic, antibacterial, and antiulcer. The present research investigation sought to identify the phytochemical components and assess the hemostatic impact of Dracaena cinnabri extracts in aqueous, ethanol, and chloroform forms. Soxhlet extraction has been employed to isolate and identify secondary metabolites in plants. Several wide
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Written by Paizildaev Timur
Published on Issue 1 Vol 17, 2026
Male reproductive health is increasingly affected by environmental pollution, yet most studies focus on semen quality alone, overlooking sexual function as a relevant functional outcome. The main objective of our study is to evaluate the combined effect of the environment on men's sexual and reproductive functions by an integrated clinical-functional approach based on the International Classification of Functioning, Disability and Health (ICF). A cross-sectional study was conducted on 216 me
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Written by Yulia Sergeevna Matlahova
Published on Issue 1 Vol 17, 2026
This article presents the results of a retrospective cohort study conducted in perinatal centers of Stavropol and Vladikavkaz between 2023 and 2025. The study aimed to compare pregnancy, delivery, and neonatal outcomes during the first three months of life in women with primary toxoplasmosis based on whether they received specific therapy. The study included 110 women who received treatment, 40 women who declined therapy, and 48 non-infected pregnant women as a control group. In the treatment gr
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Written by Zalina Yuryevna Sozaeva
Published on Issue 1 Vol 17, 2026
Russia has seen a steady increase in children's participation in organized sports. Aesthetic sports, which impose strict requirements on body shape and weight, are particularly popular among young female athletes. Intensive training combined with dietary restrictions creates a risk of relative energy deficiency in sport, a condition that negatively affects the reproductive, cardiovascular, and skeletal systems. This study assessed the prevalence and patterns of health disorders in adolescent
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Written by Nifizat Seyfudinovna Kurbanova
Published on Issue 1 Vol 17, 2026
A short interpregnancy interval is a known risk factor for adverse pregnancy outcomes. However, the effectiveness of multivitamin support in women with metabolic depletion from a prior pregnancy and lactation combined with chronic prenatal stress remains poorly understood. This study examined how chronic prenatal stress, modeling a short interpregnancy interval, affects pregnancy and offspring development in rats and whether multivitamins are protective. We used 80 female Wistar rats divided int
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Written by Mansur Lechievich Muradov
Published on Issue 1 Vol 17, 2026
This study aimed to evaluate the efficacy and safety of Caucasica Adaptogen Complex in improving vitamin and mineral status in women of reproductive age living in Southern Russia and the North Caucasus. The study included a subgroup of women with limited sun exposure due to wearing covered clothing. A total of 240 female students aged 18 to 25 years from Ingush State University and Dagestan State Medical University took part in the research. Participants were divided into three equal groups: a s
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Written by Yasameen Nasih Tawfeeq
Published on Issue 1 Vol 17, 2026
This analytical cross-sectional study aimed to investigate and compare serum and salivary fructosamine and sestrin-2 levels in type 2 diabetic mellitus (T2DM) patients and controls. Methods: Ninety eight participants were enrolled in this study and subdivided into 2 subgroups, the first group (G2), which represented the control group, consisted of (49) individuals, and the forty-eight patients with DM represented the second group (G1). Serum and saliva samples collected from fasting subjects. Se
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Written by Ali Ghassan Kanaan
Published on Issue 1 Vol 17, 2026
The cardiovascular safety of xanthine oxidase inhibitors in complex patient populations has emerged as a critical clinical consideration following conflicting evidence from major trials. This review synthesizes current evidence on the cardiovascular safety of febuxostat versus allopurinol in patient populations characterized by comorbidities, including chronic kidney disease, diabetes mellitus, and Asian ethnicity. There are raised concerns about the increased cardiovascular and all-cause mortal
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Written by Ferial Zeried
Published on Issue 1 Vol 17, 2026
To compare the subfoveal, parafoveal, and peripapillary choroidal thickness in amblyopic eyes with fellow and control eyes. Twelve control eyes, six fellow eyes, and six amblyopic eyes in this cross-sectional study. Choroidal thickness was measured by the enhanced-depth imaging technique of optical coherence tomography in all subjects. Choroidal thickness was measured at the subfoveal area and at 1000 mm intervals to the nasal and temporal to the fovea up to 2000 mm. The mean age was 8.75 ± 2.73
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Written by Yosra Alhindi
Published on Issue 1 Vol 17, 2026
Biosimilars are essential for improving healthcare access and sustainability; however, their adoption is strongly influenced by the public perception, knowledge, and trust. The curremt study aimed to comprehensively evaluate awareness, trust, acceptance, and related beliefs toward biosimilars among the general public in Saudi Arabia. A cross-sectional survey was conducted by the use of a structured bilingual questionnaire (35 items). Data from 512 participants were analyzed using descriptive st
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Written by Mohammed Merzouki
Published on Issue 1 Vol 17, 2026
The identification of novel acetylcholinesterase inhibitors remains a key strategy for the treatment of Alzheimer’s disease. In this study, a series of chalcone derivatives was evaluated using an integrated in silico approach combining ADMET prediction, BOILED-Egg analysis, and molecular docking. The pharmacokinetic assessment revealed favorable drug-likeness profiles, along with good predicted gastrointestinal absorption for most compounds. In addition, the BOILED-Egg model suggested potential
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Written by Aida Soslanovna Garisova
Published on Issue 1 Vol 17, 2026
This study aimed to evaluate the effect of continuing or discontinuing statin therapy during pregnancy on maternal lipid profile, maternal complications, and neonatal outcomes in women who took statins before pregnancy. A retrospective cohort study included 180 women who took statins before pregnancy and delivered at perinatal centers in Vladikavkaz between 2021 and 2025. Participants were divided into two groups: those who continued statins during pregnancy (n=94) and those who discontinued the
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