Resistin, a hormone secreted by adipose tissue and immune cells, has a key role in the diagnosis and treatment of many inflammatory and metabolic disorders. However, the precise role of resistin in the human body remains to be studied further. Sixty-seven individuals were involved in this study and divided into 2 groups: 36 patients with stage III periodontitis (case group) and 31 healthy individuals (control group). In addition to their ages, sexes, and body mass index, serum levels of resistin and vitamins A, C, D, and E, as well as salivary matrix metalloproteinase-8, were measured. There was no significant difference in age, gender, or BMI between the study groups. However, the levels of resistin, vitamins A, C, D, and E, and MMP-8 were significantly different. Furthermore, resistin had a strong and significant negative correlation with vitamin C, a moderate and significant negative correlation with vitamin A, and a moderate and significant positive correlation with salivary metalloproteinase-8. The study demonstrated that resistin has strong prognostic value in stage III periodontitis.
