Written by Iman Aslambekovna Gulaeva
Published on Issue 2 Vol 17, 2026
Recurrent epistaxis in adults affects 5–8% of the population, yet its causes often remain unrecognized, and patients receive only local treatment for years without a proper systemic work‑up. This review aims to summarize current evidence on the etiology, diagnosis, and consequences of recurrent epistaxis and to propose a practical diagnostic algorithm for primary care physicians. A narrative review of the literature was conducted using PubMed, Scopus, and E-Library databases over the last 15 yea
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Written by Wassan Raheem Mubark Al Khafaji
Published on Issue 2 Vol 17, 2026
The contraceptive should be highly effective, easy to reverse, have minimal side effects, and require highly compliant patients to be accepted by females and to reduce unplanned pregnancy. Implanon is considered one of the long-acting reversible contraception free from estrogenic side effects. Objectives: To assess acceptance of Implanon as a contraceptive and explore its advantages and adverse effects among users. This prospective study recruited 230 females who wanted an effective contraceptiv
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Written by Bernabe Canqui Flores
Published on Issue 2 Vol 17, 2026
Bioprocess optimization depends on understanding many interacting variables that rarely change independently. Temperature, pH, dissolved oxygen, aeration, agitation, substrate feed, and base addition often move together across a batch, creating strongly correlated process trajectories rather than simple one-factor effects. Multivariate techniques such as principal component analysis and partial least squares regression are therefore natural tools for reducing dimensionality, monitoring deviation
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Written by Zalina Yuryevna Sozaeva
Published on Issue 2 Vol 17, 2026
Metabolically dysregulated steatotic liver disease (MASLD) affects approximately one-third of the global adult population. This narrative review presents the clinical profile of the contemporary patient with MASLD, focusing on the systemic nature of the disease and risk stratification. MASLD is a systemic metabolic disorder in which hepatic steatosis serves as a marker of insulin resistance, systemic inflammation, and atherogenic dyslipidemia. The leading cause of death in MASLD patients is card
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Written by Eapak Qasim Hasan
Published on Issue 2 Vol 17, 2026
The reliable biomarkers are essential for enhancing the diagnosis and monitoring of pediatric type 1 diabetes mellitus (T1DM), while the clinical spectrum of circulating microRNAs (miRNAs) depfigends on the accurate normalization with reference to genes. The study assessed the expression and diagnostic ability of circulating miR-1 and miR-155 in 70 children with T1DM (9.8 ± 2.7 years; 40 males and 30 females) and 30 healthy cases matched for age and sex from Kirkuk, Iraq. We extracted serum RNA
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Written by Kolberg Natalia Alexandrovna
Published on Issue 2 Vol 17, 2026
This study provides an exhaustive toxicological and biotechnological evaluation of "Bursanatal," a novel veterinary immunomodulator derived from the lymphoid tissue of the avian Bursa of Fabricius. The drug’s active complex consists of low-molecular-weight regulatory peptides (1–10 kDa) obtained through a specialized multi-stage extraction and ultrafiltration process. The experimental design included an assessment of acute and subchronic toxicity (30-day oral and intraperitoneal administration)
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Written by Haimn Abdulbassit Tawfiq
Published on Issue 2 Vol 17, 2026
Visceral leishmaniasis caused by Leishmania donovani is still a life-threatening disease with limited therapeutic options. The poly(A)-binding protein (PABP) is essential for post-transcriptional gene regulation in trypanosomatids and represents a parasite-privileged drug target. To comparatively evaluate two mechanistically distinct PABP-targeting ssDNA aptamers, AP-11 (poly(A)-competitive) and AP-7 (non-competitive), complexed with Lipofectamine 2000 against L. donovani amastigotes. G
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Written by Poznyakovsky Valeriy Mikhailovich
Published on Issue 2 Vol 17, 2026
This research presents a novel biotechnological approach for the development of an 'all-purpose' protein substance, "Metacollagen Silicon+", designed for specialized products with tailored functional properties. The core innovation lies in the enzymatic hydrolysis of animal-derived collagen, primarily bovine gelatin, using fungal alkaline protease (Protosem C). This process is characterized by mild, naturally analogous biochemical conditions, operating without pH pre-adjustment. A key di
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