The study aims to investigate the epidemiology and complications of HIV/AIDS among Saudis in Riyadh, using data from King Khalid University Hospital and other governmental hospitals. A retrospective analysis was conducted using data from positive HIV/AIDS cases reported to King Khalid University Hospital and other governmental hospitals. The study found a higher prevalence of HIV/AIDS among males, with most cases occurring in the 15-29 and 30-44 age groups. Employed individuals and those with higher educational levels showed a higher prevalence of infection. Sexual contact was identified as the major transmission mode. Individuals without a registered medical history had the highest prevalence, followed by those with lung and diabetes conditions. Ocular manifestations, such as CMV retinitis, were noted among HIV-positive patients, highlighting the need for comprehensive healthcare services. The study highlights gender differences in HIV/AIDS prevalence, with males being more affected. The most impacted age group is 30-44 years, suggesting a need for targeted interventions. Factors like occupation, education, and ocular complications underscore the necessity for comprehensive HIV/AIDS prevention and care strategies in the Saudi population.