Issue 4 Volume 14 (2023)

Methotrexate (MTX) is a widely administered drug to treat inflammatory, and autoimmune diseases and malignant tumors. Sadly, its use harms several organs, including kidney impairment. This study aimed to determine if the ethanolic extract of Paeonia officinalis (P. officinalis) roots might protect the kidneys from the damage caused by MTX. GC-MS technique investigated the analysis of active constituents of P. officinalis root extract. Rats were administered P. officinalis extract

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Hantaviruse emerging as a potent zoonotic genus transmitted through rodents, a significant global public health threat, amplifying epidemics with heightened mortality rates. Despite the urgency for effective interventions, the absence of a secure vaccine or antiviral drug against hantavirus disease intensifies the challenge. This study aims to create a strong strategy for computer-aided drug design by utilizing modern computational methodologies. Among the goals include finding critical viral ta

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Staphylococcus aureus poses a cause of concern in various healthcare settings, causing a number of infections ranging from mild to severe. The evolution of new genetically distinct multi-drug resistant strains, such as the Methicillin-Resistant Staphylococcus aureus, has only amplified the problem. Having efficient data on the local antimicrobial susceptibility pattern of this pathogen is necessary for the selection of appropriate antibiotics for combating infections that may arise from Staphylo

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Spinal cord injury is a disabling neurological disease. Despite recent clinical improvements in the methods of diagnosis, survival, and well-being of patients with injuries, there are still serious problems in the treatment of neurological and functional disorders of these patients. This slow progression is mainly because of the complexity of the pathophysiology of spinal cord injury and the extensive and numerous physiological and biochemical changes that happen in the injured spinal cord. For

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Considering the importance of learning and memory and the effects of sleep deprivation on these cognitive functions and knowing that sex hormones have an effect on the sleep and wake cycle in both sexes, this study was designed to investigate the effects of sleep deprivation and sex hormones on learning and memory. Sleep is necessary for the development and survival of the brain and increases the capacity of the brain for cognitive actions. After learning, sleep consolidates newly encoded memori

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The study discusses the challenges associated with the HNSCC metastasis and aims to identify hub genes related to the Cancer Stem Cells and metastasis in HNSCC through bioinformatics analysis. HNSCC is a prevalent type of cancer having a low five-year rate of survival, largely due to advanced stages at diagnosis and distant metastasis. The study hypothesizes that CTCs with CSC characteristics are responsible for metastasis. To investigate, we utilized mRNA-based stemness index (mRNAsi) and WGCNA

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Fruits are a vital source of nutrients for human health, containing carbohydrates, minerals, vitamins, and amino acids. However, their nutritional value also makes them favorable for the growth of microorganisms. Dried fruits, can be susceptible to fungal contamination, which can pose significant health risks. In a study conducted in Jeddah, Saudi Arabia, a total of 180 imported and local dried fruit samples, including raisins, dates, and apricot, were purchased from local markets. The study inv

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Phytoestrogens are plant chemicals that can act like the hormone estrogen in the body. They can interfere with the body’s natural hormone balance and cause problems with development and reproduction. This study aimed to investigate whether garlic (Allium sativum) and caraway (Carum carvi L.) oils have estrogenic effects on male reproductive hormones, testicular tissue, and function. The study used three groups of six male Rattus rattus rats each. The control group received distilled water,

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Algal technologies have advanced significantly over the past few decades. Biopharmaceuticals, nutraceuticals, animal feed, and renewable energy are among the applications of microalgae that have recently attracted significant attention worldwide. In addition to their use in modern agriculture, the fascinating group of organisms can also be used in human health, as food additives, as they facilitate nutrient availability. In recent studies, algal biomass was demonstrated to be bene

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The objective of this study is to identify potential targets within the SARS-CoV-2 RdRp for the discovery of novel inhibitors derived from therapeutic natural compounds sourced from aromatic and medicinal plants. In the course of this study, a library was generated containing five naturally occurring flavone derivatives (4a, 4b, 4c, 4d, and 4e) in conjunction with the standard favipiravir-RTP. The compounds underwent an in-silico methodology involving critical steps, including (a) evaluating ADM

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Phosphoric acid (H3PO4), commonly derived from phosphate rock, is vital in industry as it could be employed in numerous processes. Several techniques were used to purify H3PO4. In the current work, natural and H2SO4-activated clays were used to reduce cadmium (Cd) and magnesium (Mg) ions from the H3PO4 solution through the adsorption method. The solid materials were characterized using several analytical methods including Elemental analysis, Scanning Electron Microscopy (SEM), Fourier Transform

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Safflower oilseed is a crop native to Egypt and India with arid climates. Global warming in the world requires an alternative approach to well-known oilseeds (sunflower, rapeseed). Many years of research have been carried out to study the culture of safflower oilseed in contrasting natural conditions: Russia, Southern Kazakhstan, and Tajikistan. The goal was to study the biological characteristics, productivity, accumulation of oil content, and the manifestation of the main disease in arid condi

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