Quick access

Full HTML PDF
Views: 93

Downloads: 40
Share Article:
2023 Volume 14 Issue 4

Ameliorating Effect of Paeonia officinalis on Methotrexate-Induced Renal Toxicity in Rats: Antioxidant and Anti-inflammatory Mechanisms


,
  1. Department of Biological Sciences, College of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
  2. Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah, Saudi Arabia.
Abstract

Methotrexate (MTX) is a widely administered drug to treat inflammatory, and autoimmune diseases and malignant tumors. Sadly, its use harms several organs, including kidney impairment. This study aimed to determine if the ethanolic extract of Paeonia officinalis (P. officinalis) roots might protect the kidneys from the damage caused by MTX. GC-MS technique investigated the analysis of active constituents of P. officinalis root extract. Rats were administered P. officinalis extract (200 mg/kg/day orally) with or without MTX (20 mg/kg once i.p. at day 9) for 14 days. GC-MS study of P. officinalis roots extract revealed the presence of 17 phytochemical substances, including octacosane, retinol acetate, nonacosane, tricin methyl ether, casticin, and (-)-catechin gallate. Increases in blood urea and creatinine as well as several pathological abnormalities in renal tissue and tubules, were all generated by MTX when compared to the control, indicating nephrotoxic effects. The oxidative stress brought on by MTX has been demonstrated as a decrease in renal superoxide dismutase (SOD) activity and an increase in malondialdehyde (MDA) content. By increasing renal interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-α), MTX also caused renal inflammation. Pretreatment of MTX-injected rats with P. officinalis root extract improved all oxidative and inflammatory indicators examined as well as kidney functional and structural indices. The current study first demonstrates the protective effect of P. officinalis root extract against MTX-induced kidney damage in rats. It may be due to its antioxidant and anti-inflammatory active components.


How to cite this article
Vancouver
Qari SA, Mansoury MMS. Ameliorating Effect of Paeonia officinalis on Methotrexate-Induced Renal Toxicity in Rats: Antioxidant and Anti-inflammatory Mechanisms. J Biochem Technol. 2023;14(4):1-8. https://doi.org/10.51847/6tAVg2BiBF
APA
Qari, S. A., & Mansoury, M. M. S. (2023). Ameliorating Effect of Paeonia officinalis on Methotrexate-Induced Renal Toxicity in Rats: Antioxidant and Anti-inflammatory Mechanisms. Journal of Biochemical Technology, 14(4), 1-8. https://doi.org/10.51847/6tAVg2BiBF
INDEXING
ESCI, SCIRUS, BiologyBrowser, Chemical Abstracts, CABI, Intute catalogue, Science Central, EBSCOhost databases, Genamics JournalSeek, Open J gate, Ulrich's, Academic Journals Database, CASSI, ACS (American Chemical Society), CiteFactor, and many other international scientific databases.

JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a double-blind peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

Publish with us


Sevas Publishing
Komatipalli Post, Bobbili Mandal, Vizianagaram Dt,
Andhra Pradesh (St), India, Postal Code: 535558

Publishing steps

1.Prepare
your paper
2.Submit
and revise
3.Track
your research
4.Share
and promote
This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative