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2023 Volume 14 Issue 4

Ameliorating Effect of Paeonia officinalis on Methotrexate-Induced Renal Toxicity in Rats: Antioxidant and Anti-inflammatory Mechanisms


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Abstract

Methotrexate (MTX) is a widely administered drug to treat inflammatory, and autoimmune diseases and malignant tumors. Sadly, its use harms several organs, including kidney impairment. This study aimed to determine if the ethanolic extract of Paeonia officinalis (P. officinalis) roots might protect the kidneys from the damage caused by MTX. GC-MS technique investigated the analysis of active constituents of P. officinalis root extract. Rats were administered P. officinalis extract (200 mg/kg/day orally) with or without MTX (20 mg/kg once i.p. at day 9) for 14 days. GC-MS study of P. officinalis roots extract revealed the presence of 17 phytochemical substances, including octacosane, retinol acetate, nonacosane, tricin methyl ether, casticin, and (-)-catechin gallate. Increases in blood urea and creatinine as well as several pathological abnormalities in renal tissue and tubules, were all generated by MTX when compared to the control, indicating nephrotoxic effects. The oxidative stress brought on by MTX has been demonstrated as a decrease in renal superoxide dismutase (SOD) activity and an increase in malondialdehyde (MDA) content. By increasing renal interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-α), MTX also caused renal inflammation. Pretreatment of MTX-injected rats with P. officinalis root extract improved all oxidative and inflammatory indicators examined as well as kidney functional and structural indices. The current study first demonstrates the protective effect of P. officinalis root extract against MTX-induced kidney damage in rats. It may be due to its antioxidant and anti-inflammatory active components.


How to cite this article
Vancouver
Qari SA, Mansoury MMS. Ameliorating Effect of Paeonia officinalis on Methotrexate-Induced Renal Toxicity in Rats: Antioxidant and Anti-inflammatory Mechanisms. J Biochem Technol. 2023;14(4):1-8. https://doi.org/10.51847/6tAVg2BiBF
APA
Qari, S. A., & Mansoury, M. M. S. (2023). Ameliorating Effect of Paeonia officinalis on Methotrexate-Induced Renal Toxicity in Rats: Antioxidant and Anti-inflammatory Mechanisms. Journal of Biochemical Technology, 14(4), 1-8. https://doi.org/10.51847/6tAVg2BiBF
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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a double-blind peer reviewed International Journal published by the Deniz Publication on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal of Biochemical Technology provides a publication on all aspects of biochemistry, biotechnology & bioinformatics and applications in biology and medicine. Areas of high interest cover new advances in enzymatic and protein mechanisms; applied molecular genetics and biotechnology; computational biology, genomics and proteomics; metabolic & tissue engineering; medical, environmental, Pharmacy and pharmaceutical chemistry, food and agro-biotechnology.

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative