Staphylococcus aureus poses a cause of concern in various healthcare settings, causing a number of infections ranging from mild to severe. The evolution of new genetically distinct multi-drug resistant strains, such as the Methicillin-Resistant Staphylococcus aureus, has only amplified the problem. Having efficient data on the local antimicrobial susceptibility pattern of this pathogen is necessary for the selection of appropriate antibiotics for combating infections that may arise from Staphylococcus aureus. To characterize methicillin-resistant staphylococcus aureus among adult out-patients visiting Delta State University Teaching Hospital, for each sample obtained, staphylococcus aureus was first isolated, and the identity of the isolates was confirmed by carrying out Biochemical reactions. Briefly, a Mueller-Hinton agar plate was prepared, and the test organism was inoculated. Results were interpreted as resistant or susceptible. Out of 95 samples taken and tested, Staphylococcus aureus accounted for 25 (26.7%). Antibiotic susceptibility testing carried out using the Disk diffusion method showed that 68% of specimens of confirmed Staphylococcus aureus were resistant to Oxacillin. About 32% of isolates were sensitive to it. The findings of this study show that the resistant strain of Staphylococcus aureus is the predominant strain considered in the study population. This will be a guide in proper prescription to prevent further increase in bacteria resistance.