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2023 Volume 14 Issue 4

Integrated Bioinformatics Approach Unveils Genes Linked to Metastasis in Head and Neck Squamous Cell Carcinoma


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Abstract

The study discusses the challenges associated with the HNSCC metastasis and aims to identify hub genes related to the Cancer Stem Cells and metastasis in HNSCC through bioinformatics analysis. HNSCC is a prevalent type of cancer having a low five-year rate of survival, largely due to advanced stages at diagnosis and distant metastasis. The study hypothesizes that CTCs with CSC characteristics are responsible for metastasis. To investigate, we utilized mRNA-based stemness index (mRNAsi) and WGCNA on transcriptomic data by TCGA HNSCC cohort. The study involved multiple analytical steps, including DGE analysis, co-expression network, functional enrichment, hub gene identification, PPI network, and survival evaluation. The results revealed 18 hub genes associated with CSCs and metastasis in HNSCC. Further screening narrowed the hub gene list to nine genes, CDC45, MCM5, ASF1B, RFC4, E2F1, TK1, CHTF18, CENPM, and CDCA3.These genes have been discovered to be up-regulated in the samples of HNSCC compared to normal tissues. Highlighted for potential prognostic significance in HNSCC patients, CHTF18 and CDC45, with CDC45 playing a role in DNA replication, are associated with metastasis and CSC-like behavior. The study offers insights into potential hub genes associated with CSCs and metastasis in HNSCC. However, further experimental validation and clinical data integration are necessary to confirm these findings and establish clinical relevance. This study utilizes bioinformatics tools to identify genes influencing metastatic behavior in HNSCC, revealing potential therapeutic targets and underscoring the intricacies of cancer metastasis. Other hub genes are linked to various cancers, promoting invasion, proliferation, and migration.


How to cite this article
Vancouver
Vardhan NRH, Ladani RK, Reddy AR. Integrated Bioinformatics Approach Unveils Genes Linked to Metastasis in Head and Neck Squamous Cell Carcinoma. J Biochem Technol. 2023;14(4):31-44. https://doi.org/10.51847/oaS45jOPi7
APA
Vardhan, N. R. H., Ladani, R. K., & Reddy, A. R. (2023). Integrated Bioinformatics Approach Unveils Genes Linked to Metastasis in Head and Neck Squamous Cell Carcinoma. Journal of Biochemical Technology, 14(4), 31-44. https://doi.org/10.51847/oaS45jOPi7
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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a double-blind peer reviewed International Journal published by the Deniz Publication on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative