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2023 Volume 14 Issue 4

Impact of Garlic and Caraway Oils on Reproductive Hormones Profile and Testicular Histopathology of Male Rats


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Abstract

Phytoestrogens are plant chemicals that can act like the hormone estrogen in the body. They can interfere with the body’s natural hormone balance and cause problems with development and reproduction. This study aimed to investigate whether garlic (Allium sativum) and caraway (Carum carvi L.) oils have estrogenic effects on male reproductive hormones, testicular tissue, and function. The study used three groups of six male Rattus rattus rats each. The control group received distilled water, while the garlic and caraway groups received the oils by gavage (feeding tube) at a dose of 1 ml/kg. After 30 days, blood, epididymis, and testis samples were collected from all rats for biochemical analysis, sperm analysis, and histological examination. Administering male rats garlic oil significantly decreased sperm motility, concentration, and viability. Both oils significantly decreased testosterone levels compared to the control values. They both significantly raised prolactin levels in the blood. Garlic oil, in particular, increased the percentage of abnormal sperm and caused the seminiferous tubules and testes to degenerate. However, the sperm quality, the seminiferous tubules, and the testes of rats that ingested caraway oil were almost normal. The results of this study suggest that garlic oil may produce some harm concerning male rats’ fertility (testes histology and reproductive hormones). In contrast, caraway oil is considered safer concerning testicular histology. More research is needed to see if garlic and caraway oils have an effect on male sex hormones and sperm production in humans.


How to cite this article
Vancouver
Okasha HS, Helal EGE, Huwait EAH, Khattab HAEH. Impact of Garlic and Caraway Oils on Reproductive Hormones Profile and Testicular Histopathology of Male Rats. J Biochem Technol. 2023;14(4):56-63. https://doi.org/10.51847/52GucRuHZH
APA
Okasha, H. S., Helal, E. G. E., Huwait, E. A. H., & Khattab, H. A. E. H. (2023). Impact of Garlic and Caraway Oils on Reproductive Hormones Profile and Testicular Histopathology of Male Rats. Journal of Biochemical Technology, 14(4), 56-63. https://doi.org/10.51847/52GucRuHZH
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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a double-blind peer reviewed International Journal published by the Deniz Publication on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

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FOCUS AND SCOPE
Journal Of Biochemical Technology Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative