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2024 Volume 15 Issue 2

Studying the Effects of Capparis Spinosa Hydroalcoholic Extract on Glucose Metabolism Pathways in Rat Liver Cells

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  1. Department of Food, Environmental and Nutritional Sciences (DeFENS), Division of Human Nutrition, Università degli Studi di Milano, Milano, Italy.
  2. Department of Biology, College of Science, University of Bahrain, Sakhir Campus P. O. Box 32038, Bahrain.

  3. IRCCS Mondino Foundation, 27100 Pavia, Italy.

  4. Unit of Human and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy.

It is necessary to find new drugs with fewer side impacts to decrease sugar in diabetics. This research aimed to investigate the impact of Capparis spinosa extract on the vital enzymes of glucose metabolism in diabetic male rats' liver cells. In the current study, a total of 60 rats were randomly divided into 6 groups. Diabetes was induced by streptozotocin intraperitoneal injection at a dose of 50 mg/kg. Insulin hormone and serum glucose were measured with the relevant kit, the activity of hexokinase and glucokinase enzymes was done by manual method and the expression of glucose 6 phosphatase and phosphofructokinase gene was done by Real Time-PCR method. Data were analyzed using the Kruskal-Wallis non-parametric test and Mann-Whitney post hoc test. The obtained results showed that the administration of the extract reduced the glucose serum level and increased the serum level of glucokinase and insulin and the phosphofructokinase-1 genes expression level in all groups receiving the extract compared to the control groups, and the average activity of the hexokinase enzyme and the expression of the glucose gene 6 phosphatase showed a significant difference among most groups (P<0.001). According to the findings, the treatment of diabetic rats with Capparis spinosa extract causes a significant reduction in blood sugar and an increase in the serum insulin amount and also causes an improvement in the enzyme activity involved in glycolysis. Thus, it seems that the consumption of this fruit has a good impact on insulin secretion, blood sugar, and sugar metabolism.

How to cite this article
Marino M, Riso P, Allehdan S, Rondanelli M, Perna S, Rafique A. Studying the Effects of Capparis Spinosa Hydroalcoholic Extract on Glucose Metabolism Pathways in Rat Liver Cells. J Biochem Technol. 2024;15(2):12-7. https://doi.org/10.51847/mH1c2b2Sea
Marino, M., Riso, P., Allehdan, S., Rondanelli, M., Perna, S., & Rafique, A. (2024). Studying the Effects of Capparis Spinosa Hydroalcoholic Extract on Glucose Metabolism Pathways in Rat Liver Cells. Journal of Biochemical Technology, 15(2), 12-17. https://doi.org/10.51847/mH1c2b2Sea
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Journal of Biochemical Technology is a double-blind peer reviewed International Journal published by the Deniz Publication on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

Journal of Biochemical Technology provides a publication on all aspects of biochemistry, biotechnology & bioinformatics and applications in biology and medicine. Areas of high interest cover new advances in enzymatic and protein mechanisms; applied molecular genetics and biotechnology; computational biology, genomics and proteomics; metabolic & tissue engineering; medical, environmental, Pharmacy and pharmaceutical chemistry, food and agro-biotechnology.

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