Written by Zubair Ahmad
Published On Issue 4 Vol 15, 2024
Letter to Editor Recent breakthroughs in the metabolism of tumors have revolutionized our comprehension of cancer research, presenting new sites for therapeutic exploration ( Vander Heiden & DeBerardinis, 2017 ). Cancer cells show distinct metabolic adaptations to support their unbridled proliferation and survival. Investigating and analyzing these metabolic alterations has become a paramount focus of cancer research. In this editorial, we explore the most recent developments in tumor metabolism
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Written by Bing Jiang
Published On Issue 4 Vol 15, 2024
Peroxidases are proteins that contain heme and are widely active in plants, microorganisms, and animals. In this review study on plant peroxidases, in addition to introducing them, how to measure the activity of the enzyme, checking the number of isozymes, and tracking the structural changes of the enzyme have also been examined. This two-substrate enzyme, which converts hydrogen peroxide into water, oxidizes many organic and inorganic substrates during its catalysis, all of which can be used to
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Written by Sarad Pawar Naik Bukke
Published On Issue 4 Vol 15, 2024
Alendronate (ALD), when administered orally, has several limitations, including poor bioavailability and gastrointestinal irritation. This study addresses the need for a sustained local delivery system for ALD by fabricating Hydroxyapatite (HA) hollow microspheres using a simple template-directed method with mustard seeds as the template. ALD was adsorbed onto the surface of the HA hollow microspheres at varying concentrations (0.05 µM to 0.2 µM). The microsphere characteristics properties of th
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Written by Coulibaly Songuigama
Published On Issue 4 Vol 15, 2024
Research for new drugs to combat drug resistance in tuberculosis bacilli is one of the solutions to overcome this disease. In this sense, we have designed, synthesized, and fully characterized the chemical structures of about 20 derivatives of 1,10-phenanthrolinone. The evaluation of the antitubercular activities of Mycobacterium tuberculosis revealed that some of these compounds are highly active. Furthermore, the research of the structure-activity connection showed that the derivatives with th
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Written by Lalitha Tanjore Arunachalam
Published On Issue 4 Vol 15, 2024
Proinflammatory cytokines play a critical role in the destruction of periodontal tissues. DNA-sensing inflammasomes, such as AIM2 and IFI16, are key mediators in the secretion of IL-1 and IL-18 and facilitate pyroptosis in periodontitis. Andrographolide and resveratrol are phytocompounds known for their anti-inflammatory effects, though their precise mechanisms of action remain uncertain. This study aimed to elucidate the molecular interactions of andrographolide and resveratrol with AIM2 and IF
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Written by Idoko Alexander
Published On Issue 4 Vol 15, 2024
Flavonoid-rich plant compounds are known for their beneficial multi-health functions. The liver and kidney protective potentials of fresh lime juice (FLJ), 50% FLJ and 50% honey combination (MIX), and the methanol flavonoid-rich fraction of lime juice (MFLJ) were examined in this study. Three sets of eighteen male neonatal Wistar rats (phase 1) were utilized, totaling fifty-four. Rats in group III were given a diet rich in protein for 14 days, and those with a Lee index of 0.3 or higher were cla
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