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2024 Volume 15 Issue 2

Investigating the Effects of Diabetes Mellitus on Several Biochemical Parameters and Histopathological Changes of Some Organs in Rats


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  1. Department of Analytical Chemistry, Medical School, Autonomous University of Nuevo Leon, Monterrey, Mexico.
  2. Liver Unit at the “Dr. José E. González” University Hospital of the Autonomous University of Nuevo Leon, Monterrey, Mexico.

Abstract

One of the metabolic diseases that occurs frequently in elderly women is diabetes. In this study, the effects of diabetes on some biochemical parameters and histopathological changes in rats were investigated. In this experimental-interventional study, adult female rats were divided into four groups of 8. The first control group, the second ovariectomy group (for 55 weeks), the third induced diabetes group in the last 5 weeks of the study in mice with ovaries, and the fourth ovariectomy group (for 55 weeks) and induced diabetes in the last 5 weeks of the study. Pathological changes in lung, pancreas, kidney, and liver tissues and some serum biochemical indices were determined in each group at the end of the study. Diabetic and ovariectomized diabetic rats revealed an increase in blood glucose, alkaline phosphatase, alanine aminotransferase, gamma-glutamyl transferase, aspartate aminotransferase, urea, high-density lipoprotein, calcium, and triglyceride compared to the control group (p < 0.05). Ovariectomized rats showed an increase in cholesterol, low-density lipoprotein, high-density lipoprotein, lactate dehydrogenase, and triglyceride compared to the control group (p < 0.05). The findings revealed that the long-term reduction of estrogen in ovariectomized diabetic rats can have beneficial changes in reducing the serum levels of glucose, aspartate aminotransferase, alanine aminotransferase, urea, gamma-glutamyl transferase, very low-density lipoprotein, and triglyceride compared to non-ovariectomized diabetic rats.


How to cite this article
Vancouver
Delgado-Montemayor C, Cordero-Pérez P, Salazar-Aranda R, Waksman-Minsky N. Investigating the Effects of Diabetes Mellitus on Several Biochemical Parameters and Histopathological Changes of Some Organs in Rats. J Biochem Technol. 2024;15(2):33-8. https://doi.org/10.51847/z2otJnIOub
APA
Delgado-Montemayor, C., Cordero-Pérez, P., Salazar-Aranda, R., & Waksman-Minsky, N. (2024). Investigating the Effects of Diabetes Mellitus on Several Biochemical Parameters and Histopathological Changes of Some Organs in Rats. Journal of Biochemical Technology, 15(2), 33-38. https://doi.org/10.51847/z2otJnIOub
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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a double-blind peer reviewed International Journal published by the Deniz Publication on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal of Biochemical Technology provides a publication on all aspects of biochemistry, biotechnology & bioinformatics and applications in biology and medicine. Areas of high interest cover new advances in enzymatic and protein mechanisms; applied molecular genetics and biotechnology; computational biology, genomics and proteomics; metabolic & tissue engineering; medical, environmental, Pharmacy and pharmaceutical chemistry, food and agro-biotechnology.

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