Written by Mohammed Merzouki
Published on Issue 2 Vol 16, 2025
The SARS‑CoV‑2 main protease (Mpro) is indispensable for viral polyprotein maturation and therefore constitutes a prime antiviral drug target. Guided by drug‑likeness metrics, we designed a focused series of chromone‑thiophene derivatives (M1-M4) that combine a rigid, π‑rich chromone core with a sulfur‑containing hydrophobic anchor. SwissADME calculations revealed that progressive hydroxylation (0-2 OH) endows the series with ideal physicochemical parameters (MW 228-260 g mol⁻¹, cLogP 2.5-3.1, T
Read More
Written by Ashoke Hazra
Published on Issue 2 Vol 16, 2025
Zinc oxide nanoparticles (ZnO NPs) have gained significant attention in nanotechnology due to their exceptional physical and chemical properties, including a high surface area, unique optical characteristics, photosensitivity, and biocompatibility. These properties make ZnO NPs highly valuable for various biomedical and technological applications. This study focuses on the synthesis of ZnO NPs using a chemical synthesis approach, ensuring controlled particle formation. The synthesized nanopartic
Read More
Written by Zhenish Kyzy Asel
Published on Issue 2 Vol 16, 2025
Metabolic syndrome—a cluster of interrelated conditions including obesity, hypertension, dyslipidemia, and insulin resistance—is a key precursor to both type 2 diabetes and cardiovascular disease. In regions with rising burdens of non-communicable diseases, diabetes mellitus has become a leading challenge in clinical management. The narrative review presents a detailed case study of a 64-year-old patient who has insulin-dependent type 2 diabetes mellitus with peripheral neuropathy and nephropath
Read More
