Written by Mohammed Merzouki
Published on Issue 2 Vol 16, 2025
The SARS‑CoV‑2 main protease (Mpro) is indispensable for viral polyprotein maturation and therefore constitutes a prime antiviral drug target. Guided by drug‑likeness metrics, we designed a focused series of chromone‑thiophene derivatives (M1-M4) that combine a rigid, π‑rich chromone core with a sulfur‑containing hydrophobic anchor. SwissADME calculations revealed that progressive hydroxylation (0-2 OH) endows the series with ideal physicochemical parameters (MW 228-260 g mol⁻¹, cLogP 2.5-3.1, T
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Written by Ashoke Hazra
Published on Issue 2 Vol 16, 2025
Zinc oxide nanoparticles (ZnO NPs) have gained significant attention in nanotechnology due to their exceptional physical and chemical properties, including a high surface area, unique optical characteristics, photosensitivity, and biocompatibility. These properties make ZnO NPs highly valuable for various biomedical and technological applications. This study focuses on the synthesis of ZnO NPs using a chemical synthesis approach, ensuring controlled particle formation. The synthesized nanopartic
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Written by Zhenish Kyzy Asel
Published on Issue 2 Vol 16, 2025
Metabolic syndrome—a cluster of interrelated conditions including obesity, hypertension, dyslipidemia, and insulin resistance—is a key precursor to both type 2 diabetes and cardiovascular disease. In regions with rising burdens of non-communicable diseases, diabetes mellitus has become a leading challenge in clinical management. The narrative review presents a detailed case study of a 64-year-old patient who has insulin-dependent type 2 diabetes mellitus with peripheral neuropathy and nephropath
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Written by Radima Muratovna Bytdaeva
Published on Issue 2 Vol 16, 2025
This research investigates the therapeutic potential of aqueous Chlorophytum comosum extract in managing bilirubin metabolism disturbances in laboratory animals with experimentally induced toxic hepatitis. The study compared the efficacy of three treatment approaches: Chlorophytum comosum extract monotherapy, standard vitamin therapy (including vitamins B₁, B₂, B₆, B₁₂, PP, E, and C), and a combination of both treatments. The experiment involved four groups of Chinchilla breed rabbits, with toxi
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Written by Nuriiat Yahyaevna Magomedova
Published on Issue 2 Vol 16, 2025
This research investigates the therapeutic potential of aqueous Chlorophytum comosum extract in managing bilirubin metabolism disturbances in laboratory animals with experimentally induced toxic hepatitis. The study compared the efficacy of three treatment approaches: Chlorophytum comosum extract monotherapy, standard vitamin therapy (including vitamins B₁, B₂, B₆, B₁₂, PP, E, and C), and a combination of both treatments. The experiment involved four groups of Chinchilla breed rabbits, with toxi
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Written by Bislan Validovich Usmaev
Published on Issue 2 Vol 16, 2025
The present study focuses on the non-nutritional causes of dyslipidemia, including an increase in both atherogenic (LDL) and antiatherogenic (HDL) lipid fractions. The prospective study included 180 patients aged 30-65 years with a normal BMI, but persistent changes in the lipid profile that persisted despite dieting. A comprehensive analysis of endocrine, genetic, microbiomic, and environmental factors, as well as their relationship to clinical manifestations, has been performed. The results re
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Written by Valeriia Valerievna Volobueva
Published on Issue 2 Vol 16, 2025
This prospective observational study evaluated the efficacy and safety of different treatment modalities in 240 osteoarthritis (OA) patients (mean age 58.7±9.2 years; 68.3% female) at a diagnostic center in the Republic of Dagestan from 2022 to 2024. Patients were stratified into four treatment groups: NSAIDs (n=72), chondroprotectors (n=60), hyaluronic acid (HA) injections (n=54), and combination therapy (n=54). Primary outcomes included changes in pain intensity (VAS) and functional status (WO
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Written by Emil Zaurovich Isaev
Published on Issue 2 Vol 16, 2025
This study investigates the therapeutic potential of microbiome-targeted interventions for moderate-to-severe atopic dermatitis through a comprehensive clinical trial evaluating both skin and gut microbiome modulation. The randomized controlled study compared three treatment approaches: oral probiotic supplementation, topical application of commensal skin bacteria, and a combination of both therapies, against standard care in 65 patients over 12 weeks. Clinical assessments demonstrated superior
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Written by Magomed Bashir Khavazhevich Izmailov
Published on Issue 2 Vol 16, 2025
This randomized controlled trial evaluated the efficacy and safety of various hormone replacement therapy (HRT) regimens in 840 perimenopausal women aged 45-55 years. Participants were allocated to receive either transdermal 17β-estradiol with micronized progesterone, oral conjugated estrogens with medroxyprogesterone acetate, transdermal estradiol with dydrogesterone, or non-hormonal therapy for 24 months. Vasomotor symptom reduction was the main result, with safety profiles, metabolic paramete
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Written by Arsen Tovsultanov
Published on Issue 2 Vol 16, 2025
This study presents the development and preclinical evaluation of a novel osteotropic micronutrient complex (OMC) designed to enhance bone regeneration in osteopenic conditions. The formulation combines vitamin K2 (menaquinone-7), strontium citrate, fructoborate, and nano-hydroxyapatite to target multiple pathways of bone metabolism synergistically. Using an ovariectomized rat model of osteoporosis, we assessed the effects of OMC on bone mineral density (BMD), microarchitecture, biomechanical st
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Written by Polina Kozhina
Published on Issue 2 Vol 16, 2025
This study presents the results of the development and comprehensive evaluation of a novel adaptogenic herbal preparation "Ginskhizin," based on a combination of standardized extracts of Panax ginseng C.A. Mey. and Schisandra chinensis (Turcz.) Baill. The experimental work was conducted on a laboratory rat model using modern pharmacological, biochemical, and toxicological methods. The results demonstrate pronounced adaptogenic effects of the preparation, manifested in a dose-dependent increase i
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Written by Kanchi RaviPadma
Published on Issue 2 Vol 16, 2025
Rudraksha (Elaeocarpus ganitrus) is a plant that is highly revered and has been found out to be of therapeutic and spiritual value. Traditionally used as the King of Herbal Medicines in use in systems of medicine like Ayurveda, Siddha and Unani systems of medicine, it has been used both prophylactically and as a treatment. As per the mythology of the Hindus, this origin dates back to the Lord Shiva when his tears gave it more spiritual value. Through centuries Rudraksha beads have been attractin
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Written by Bagepalli Srinivas Ashok Kumar
Published on Issue 2 Vol 16, 2025
Dementia is a progressive neurodegenerative disorder marked by a decline in cognitive function, with Alzheimer’s disease being the most prevalent form. Current pharmacological treatments offer only limited symptomatic relief, prompting increasing interest in alternative strategies. Emerging evidence suggests that the plant-derived compounds may play a role as potential adjuncts in the management of dementia. This review explores the neuroprotective properties of selected medicinal plants, includ
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Written by Lex Aaron Garcia
Published on Issue 2 Vol 16, 2025
Melioidosis, a frequently underdiagnosed yet potentially fatal disease in the Philippines, is caused by Burkholderia pseudomallei, a pathogen noted for rapidly acquiring antibiotic resistance. The bacterial enzyme dethiobiotin synthetase (DTBS), which functions as a dimer, is an attractive drug target because of its essential role in biotin biosynthesis. In this study, computer-assisted drug discovery and development (CADDD) was employed to identify natural product inhibitors of the AlphaFold-pr
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Written by Ashoke Hazra
Published on Issue 2 Vol 16, 2025
The thermodynamic and kinetic behavior of green-synthesized silver nanoparticles (AgNPs) interacting with bovine serum albumin (BSA) was studied using UV–Visible spectroscopy and conductivity techniques. AgNPs prepared from Azadirachta indica leaf extract showed a surface plasmon resonance (SPR) band at 430 nm. Binding constants (K) were measured at five temperatures (298–318 K). Van't Hoff analysis provided ΔH and ΔS, while ΔG was evaluated at each temperature. The interaction is spontaneou
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Written by Alzhanat Muratovna Mustafayeva
Published on Issue 2 Vol 16, 2025
Sleep disorders and neurotic disorders in children represent a significant medical and social problem. The prevalence of insomnia in the pediatric population reaches 6%. When taking into account concomitant sleep disorders, this indicator increases to 50% among preschool children. Existing therapeutic approaches often require the development of new, safe, and effective remedies with improved compliance characteristics. The purpose of this scientific work is to develop and comprehensively study a
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Written by Hava Ali Kizi Karimova
Published on Issue 2 Vol 16, 2025
The development of effective and safe means for local wound treatment remains an urgent problem in modern medicine. The purpose of this study was to create an innovative drug in the form of an impregnated gauze bandage, ready for immediate use. The formulation is based on a synergistic combination of zinc sulfathiazole, which provides antimicrobial action and delivery of zinc ions as a regeneration cofactor, dexpanthenol, for direct stimulation of cell proliferation and epithelialization, and st
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Written by Lobach Evgenia Yurievna
Published on Issue 2 Vol 16, 2025
This article examines approaches to the comprehensive treatment and prevention of colpitis and vulvovaginal candidiasis (VVC), with a focus on the use of dietary supplements (DS). The crucial role of vaginal microflora imbalances in the development of colpitis is highlighted, justifying the use of probiotics and biocomplexes. Specific attention is given to various DS formulations, such as a Phytocomplex with black cumin oil, an Isoflavone Complex with Probiotics, a Biocomplex with fermented diet
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Written by Alexey Gennadievich Vaganov
Published on Issue 2 Vol 16, 2025
The purpose of this scientific study is to evaluate the effectiveness of intraoperative luminescence spectroscopy in reducing the incidence of postoperative complications after abdominoplasty in patients with diabetes mellitus. In the main (experimental) group, the mobilization of the skin-fat flap was performed under the control of luminescence spectroscopy to assess tissue viability, while in the control group, the standard method was used. Intraoperative parameters were evaluated, and in the
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Written by Lyubov Germanovna Aistova
Published on Issue 2 Vol 16, 2025
The purpose of this preclinical trial is to investigate the acceleration of infected wound healing processes in laboratory animals using weak, non-ionizing, non-thermal electromagnetic fields applied through a non-invasive electromagnetic therapy. The experiment was conducted at the Far East State Agrarian University between June 2023 and December 2024, involving 14 common rabbits. After inducing infected skin wounds, the rabbits were randomly divided into two equal groups on the 5th day. The co
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