Written by Mohammed Merzouki
Published on Issue 2 Vol 16, 2025
The SARS‑CoV‑2 main protease (Mpro) is indispensable for viral polyprotein maturation and therefore constitutes a prime antiviral drug target. Guided by drug‑likeness metrics, we designed a focused series of chromone‑thiophene derivatives (M1-M4) that combine a rigid, π‑rich chromone core with a sulfur‑containing hydrophobic anchor. SwissADME calculations revealed that progressive hydroxylation (0-2 OH) endows the series with ideal physicochemical parameters (MW 228-260 g mol⁻¹, cLogP 2.5-3.1, T
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Written by Ashoke Hazra
Published on Issue 2 Vol 16, 2025
Zinc oxide nanoparticles (ZnO NPs) have gained significant attention in nanotechnology due to their exceptional physical and chemical properties, including a high surface area, unique optical characteristics, photosensitivity, and biocompatibility. These properties make ZnO NPs highly valuable for various biomedical and technological applications. This study focuses on the synthesis of ZnO NPs using a chemical synthesis approach, ensuring controlled particle formation. The synthesized nanopartic
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Written by Zhenish Kyzy Asel
Published on Issue 2 Vol 16, 2025
Metabolic syndrome—a cluster of interrelated conditions including obesity, hypertension, dyslipidemia, and insulin resistance—is a key precursor to both type 2 diabetes and cardiovascular disease. In regions with rising burdens of non-communicable diseases, diabetes mellitus has become a leading challenge in clinical management. The narrative review presents a detailed case study of a 64-year-old patient who has insulin-dependent type 2 diabetes mellitus with peripheral neuropathy and nephropath
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Written by Radima Muratovna Bytdaeva
Published on Issue 2 Vol 16, 2025
This research investigates the therapeutic potential of aqueous Chlorophytum comosum extract in managing bilirubin metabolism disturbances in laboratory animals with experimentally induced toxic hepatitis. The study compared the efficacy of three treatment approaches: Chlorophytum comosum extract monotherapy, standard vitamin therapy (including vitamins B₁, B₂, B₆, B₁₂, PP, E, and C), and a combination of both treatments. The experiment involved four groups of Chinchilla breed rabbits, with toxi
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Written by Nuriiat Yahyaevna Magomedova
Published on Issue 2 Vol 16, 2025
This research investigates the therapeutic potential of aqueous Chlorophytum comosum extract in managing bilirubin metabolism disturbances in laboratory animals with experimentally induced toxic hepatitis. The study compared the efficacy of three treatment approaches: Chlorophytum comosum extract monotherapy, standard vitamin therapy (including vitamins B₁, B₂, B₆, B₁₂, PP, E, and C), and a combination of both treatments. The experiment involved four groups of Chinchilla breed rabbits, with toxi
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Written by Bislan Validovich Usmaev
Published on Issue 2 Vol 16, 2025
The present study focuses on the non-nutritional causes of dyslipidemia, including an increase in both atherogenic (LDL) and antiatherogenic (HDL) lipid fractions. The prospective study included 180 patients aged 30-65 years with a normal BMI, but persistent changes in the lipid profile that persisted despite dieting. A comprehensive analysis of endocrine, genetic, microbiomic, and environmental factors, as well as their relationship to clinical manifestations, has been performed. The results re
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Written by Valeriia Valerievna Volobueva
Published on Issue 2 Vol 16, 2025
This prospective observational study evaluated the efficacy and safety of different treatment modalities in 240 osteoarthritis (OA) patients (mean age 58.7±9.2 years; 68.3% female) at a diagnostic center in the Republic of Dagestan from 2022 to 2024. Patients were stratified into four treatment groups: NSAIDs (n=72), chondroprotectors (n=60), hyaluronic acid (HA) injections (n=54), and combination therapy (n=54). Primary outcomes included changes in pain intensity (VAS) and functional status (WO
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Written by Emil Zaurovich Isaev
Published on Issue 2 Vol 16, 2025
This study investigates the therapeutic potential of microbiome-targeted interventions for moderate-to-severe atopic dermatitis through a comprehensive clinical trial evaluating both skin and gut microbiome modulation. The randomized controlled study compared three treatment approaches: oral probiotic supplementation, topical application of commensal skin bacteria, and a combination of both therapies, against standard care in 65 patients over 12 weeks. Clinical assessments demonstrated superior
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Written by Magomed Bashir Khavazhevich Izmailov
Published on Issue 2 Vol 16, 2025
This randomized controlled trial evaluated the efficacy and safety of various hormone replacement therapy (HRT) regimens in 840 perimenopausal women aged 45-55 years. Participants were allocated to receive either transdermal 17β-estradiol with micronized progesterone, oral conjugated estrogens with medroxyprogesterone acetate, transdermal estradiol with dydrogesterone, or non-hormonal therapy for 24 months. Vasomotor symptom reduction was the main result, with safety profiles, metabolic paramete
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