Written by Melavinka Agubechirovna Sozaeva
Published on Issue 3 Vol 16, 2025
This research article presents the results of the development and experimental evaluation of prolonged-release contact lenses for use in ophthalmology. The research aimed to create innovative delivery systems capable of overcoming the limitations of traditional eye drops, such as low bioavailability and the need for frequent use. Silicone hydrogel (Senofilcon A, Lotrafilcon B) and polymer (pHEMA) matrices modified with PLGA nanoparticles and cyclodextrins were used in the work to improve the sol
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Written by Milana Ruslanovna Gedugova
Published on Issue 3 Vol 16, 2025
The present study is devoted to the study of the features of damage to the temporomandibular joint (TMJ) in patients with rheumatoid arthritis (RA) and osteoarthritis (OA). A prospective cohort study involved 128 patients divided into three groups: 42 patients with RA, 38 with OA, and 48 healthy controls. The comprehensive examination included a clinical examination, cone beam computed tomography (CBCT), magnetic resonance imaging (MRI), electromyography of the masticatory muscles, and computer
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Written by Kuppam Chandrasekhar
Published on Issue 3 Vol 16, 2025
Microbial cell factories have emerged as sustainable platforms for producing bio-commodities such as biofuels, bioplastics, and pharmaceuticals. However, achieving industrial scalability remains hindered by challenges in strain robustness, including genetic instability, metabolic burden, and environmental stress tolerance. This review explores cutting-edge strategies in microbial engineering to enhance robustness, focusing on synthetic biology tools, adaptive laboratory evolution (ALE), and syst
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Written by Kingsley Chukwuka Amaihunwa
Published on Issue 3 Vol 16, 2025
Probiotic therapeutics represent a rapidly advancing field, with particular interest directed toward the engineering of probiotic biofilms for immune modulation and gastrointestinal (GI) health. In contrast to conventional planktonic probiotic cells, biofilm-forming strains exhibit enhanced resilience, prolonged mucosal colonization, and improved immunological interactions facilitated by their extracellular polymeric substances (EPS). These attributes confer superior therapeutic consistency and
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Written by Maneri Sujana
Published on Issue 3 Vol 16, 2025
Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), present significant global health issues, with existing treatments primarily providing limited symptom relief. Consequently, there is an increasing scientific focus on the neuroprotective capabilities of medicinal plants that have been utilized in various traditional healing practices. This review examines the therapeutic properties of Ginkgo biloba, Crocus sativus
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Written by Kuppam Chandrasekhar
Published on Issue 3 Vol 16, 2025
Microbial exopolysaccharides (EPS) are high molecular weight carbohydrate polymers secreted by bacteria, fungi, and algae, representing an important class of bio-based materials with wide ranging industrial and environmental applications. These polymers are broadly classified into capsular polysaccharides, which remain tightly bound to the microbial cell surface, and slime polysaccharides, which are released into the extracellular medium. The structural diversity of EPS, determined by variations
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Written by Derouiche Samir
Published on Issue 3 Vol 16, 2025
Finding out how Proso millet aqueous extract affected osteoporosis in postmenopausal women in the Guemar El-Oued area was the aim of this study. Three groups of 32 volunteers’ women were chosen; as control and menopausal women have osteoporosis before and after Proso millet aqueous extract treatment during 30 days. Some biochemical and hematological parameters were measured. According to our findings, the osteoporosis patient group had significantly higher levels of WBC, lymphocytes, RBC, HCT, P
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Written by Danao Kishor
Published on Issue 3 Vol 16, 2025
Traditional antibiotics are often restricted by resistance, adverse effects, and diminishing potency. Hybrid drug design, which combines two pharmacophores in a single molecule, offers a new alternative. Chalcones, flavonoid derivatives possessing α, β- unsaturated carbonyl system, exhibit antibacterial, anti-inflammatory, and antidiabetic properties. The Claisen-Schmidt condensation is used to synthesize the chalcones, which are then conjugated with aspirin fragments by esterification or amidat
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Written by Roxangeluv Costiniano
Published on Issue 3 Vol 16, 2025
The human immunodeficiency virus (HIV) is the cause of acquired immunodeficiency syndrome, or AIDS, which has been a serious global health concern since its discovery in 1981. Finding novel treatment leads is crucial, as seen by the lack of effective antiretroviral drugs. To identify potential HIV-1 proteins, this study employed a technique known as pharmacophore-based virtual screening and molecular docking. Using a pharmacophore model that was created, compounds from DrugBank and an interna
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Written by Valery Petrovich Sergun
Published on Issue 3 Vol 16, 2025
This article examines the effect of taking the dietary supplements Toxidont May, Pantobiol 2, and Gepatobiol on the morphofunctional state of erythrocytes in patients. Cytochemical analysis of peripheral blood showed that consuming these dietary supplements for 6 weeks led to a significant increase (p< 0.05) in the concentration of sulfhydryl groups and lipoproteins in erythrocytes. An increase in the level of sulfhydryl groups indicates a decrease in the activity of lipid peroxidation processes
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Written by Shaik Gousiya Begam
Published on Issue 3 Vol 16, 2025
Pesticides, although used in large amounts in agriculture for pest and disease control, have a long-term presence in the soil, bringing about negative impacts on the ecosystems and people. However, one of the possibilities for dealing with the issue is through the microbial degradation of the contaminants, which is a safe and sustainable method for environmental remediation. The study was conducted to find out if the soil bacteria which can fix nitrogen, could also degrade pesticides. The soil s
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