This research investigates the therapeutic potential of aqueous Chlorophytum comosum extract in managing bilirubin metabolism disturbances in laboratory animals with experimentally induced toxic hepatitis. The study compared the efficacy of three treatment approaches: Chlorophytum comosum extract monotherapy, standard vitamin therapy (including vitamins B₁, B₂, B₆, B₁₂, PP, E, and C), and a combination of both treatments. The experiment involved four groups of Chinchilla breed rabbits, with toxic hepatitis induced by a single subcutaneous injection of carbon tetrachloride (CCl₄). Blood samples were collected daily to measure total and direct bilirubin levels using the «Lakhema» test method. Key findings revealed that CCl₄ intoxication significantly increased bilirubin levels, primarily affecting direct bilirubin. The highest bilirubin concentrations were observed on the 4th day in untreated rabbits. By the tenth day of the research, the combination therapy group notably showed the most effective reduction in bilirubin levels. The research highlights the potential of Chlorophytum comosum extract as a promising hepatoprotective agent, showing comparable efficacy to standard vitamin therapy and demonstrating additive effects when combined. These findings suggest that Chlorophytum comosum extract could serve as a valuable adjunct in managing toxic liver injuries, offering a natural alternative to conventional treatments. The study emphasizes the importance of further research into the hepatoprotective properties of plant-based remedies, particularly in addressing liver damage caused by environmental toxins and industrial pollutants. The results contribute to the growing body of evidence supporting the therapeutic potential of natural compounds in liver disease management.
