The purpose of this preclinical trial is to investigate the acceleration of infected wound healing processes in laboratory animals using weak, non-ionizing, non-thermal electromagnetic fields applied through a non-invasive electromagnetic therapy. The experiment was conducted at the Far East State Agrarian University between June 2023 and December 2024, involving 14 common rabbits. After inducing infected skin wounds, the rabbits were randomly divided into two equal groups on the 5th day. The control group received local wound treatment with saline solution only, while the experimental group underwent remote, non-invasive electromagnetic therapy. The experimental procedure continued for 17 days, followed by a 30-day observation period. Clinical blood analyses and wound exudate cultures were performed. Wound regeneration was evaluated using planimetric methods and standard statistical analysis. On day 5, leukocytosis exceeded the norm by 3.0% in the control group and by 68% in the experimental group. On day 7, the wound size had reduced by 1.0 cm in three control animals, while five animals in the experimental group showed reductions of between 0.5 and 1.0 cm. By day 9, normothermia was observed in the experimental group, whereas one rabbit in the control group exhibited hyperthermia. By day 14, no wound microflora was detected in the experimental group, unlike in the control group. Thrombocytosis was noted in the experimental group throughout the study, ultimately exceeding baseline levels by 71%. Remote non-invasive electromagnetic therapy can serve as an auxiliary method of wound regeneration, providing both local and systemic immunostimulating effects.
