Quick access

Full HTML PDF
Share Article:
2020 Volume 11 Issue 1

The Hepatoprotective Effect of Moringa Oleifera Leaf Aqueous Extract Against Cadmium-Induced Toxicity on Male Rats


Fawzia A. Alshubaily, Ebtissam Soluman Almotairi
Abstract

The fresh matter or extracts from Moringa Oleifera (MO) have antioxidant and protective effects against toxicants. The hepatoprotective effect of leaf aqueous extract was studied on cadmium-induced liver toxicity in albino rats. Thirty-six Wister rats were divided into six groups (n=6). Group I: was negative control received only distilled water, Group II: was the positive control received 11mg/kg of CdCl2, Group III and Group IV received 11mg/kg CdCl2, and concurrently treated with 250 mg/kg b.w. and 500 mg/kg MO leaf aqueous extract, respectively. The rats in groups V and VI received daily 250 mg/kg b.w. and 500 mg/kg of MO leaf aqueous extract, respectively. Cadmium toxicity damaged hepatic tissues and the liver homogenate showed increased MDA content accompanied by decreased SOD, CAT, and GSH levels, whereas the serum showed altered liver function by the increased activity of AST, ALT, ALP, GGT, and bilirubin accompanied by decreased protein and albumin. Furthermore, the administration of Moringa reversed the activities of serum hepatic enzymes nearly to their normal levels, reduced lipid peroxidation, increased the antioxidants levels, and recovered the normality of the liver. In conclusion, moringa succeeded in protecting male rats against cadmium-induced hepatotoxicity by alleviating liver injury as evidenced by histological and biochemical examinations.


How to cite this article
Alshubaily F A & Almotairi E S. The Hepatoprotective Effect of Moringa Oleifera Leaf Aqueous Extract Against Cadmium-Induced Toxicity on Male Rats. J Biochem Technol 2020;11(1):101-7
INDEXING
+ Pubmed Central, DOAJ, SCIRUS, BiologyBrowser, Chemical Abstracts, CABI, Intute catalogue, Science Central, EBSCOhost databases, Google Scholars, Genamics JournalSeek, Open J gate, Ulrich's, ResearchGate and many more.

J BIOCHEM TECH
J BIOCHEM TECH
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

Publish with us

Call for papers

Issue 4 Volume 11 - 2020

Publishing steps

1.Prepare
your paper
2.Submit
and revise
3.Track
your research
4.Share
and promote
This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative