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2020 Volume 11 Issue 3

Piliostigma thonningii leaf extract potentiates remedy to pregnancy-induced hypertension


Kayode Dasofunjo, Atamgba A. Asuk
Abstract

This research investigated the effect of Piliostigma thonningii leaf extract on maternal and offspring lipid profiles following acetaminophen-induced toxicity in Wistar rats. Twenty-five pregnant rats (180-200 g) were assigned based on their body weight to groups I-V and treated thus: animals in groups II-V were orally administered 200 mg/kg b.w acetaminophen, 200 mg/kg b.w. P. thonningii, 100 mg/kg b.w. P. thonningii +200 mg/kg b.w. acetaminophen, and 200 mg/kg P.thonningii + 200 mg/kg b.w. acetaminophen, respectively, while group I served as the control. Lipid profile assay was performed after 28 days of animal experimentation. We observed that the maternal triglyceride (TG) and HDL concentrations of group II were significantly (P<0.001) higher and lower respectively than the control and test groups, while the TG and HDL of group II offspring were significantly higher (P<0.05) than the control and group V and lower (P<0.01) than control and test groups, respectively. The maternal total cholesterol (TC) concentration of group II was significantly reduced to normal in groups IV (P<0.001) and V (P<0.01) and for LDL of groups IV (P<0.001) and V (P<0.05). The TC of group II offspring was significantly reduced in groups IV (P<0.05) and V (P<0.001) of the offspring but LDL was not altered. This report revealed that P. thonningii leaf extract reverses acetaminophen-induced toxicity in pregnancy, which is reflected in dyslipidemia vis-à-vis pregnancy-induced hypertension (PIH). Hence, P. thonningii leaf extract possesses the potential to reverse PIH and related effects on offspring with a possible reduction in the risk of preeclampsia.


How to cite this article
Dasofunjo K & Asuk A A. Piliostigma thonningii leaf extract potentiates remedy to pregnancy-induced hypertension. J Biochem Technol 2020;11(3):97-101
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J BIOCHEM TECH
J BIOCHEM TECH
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative