Quick access

Full HTML PDF
Share Article:
2020 Volume 11 Issue 2

Neurological and Biological Toxicity of Subchronic Exposure to Inhaled Benzene in Male Rats


Aysha A. Alshareef and Maha Ibrahim
Abstract

Petroleum, or what is known among the general public as benzene, contains monocyclic aromatic hydrocarbon compounds. Benzene may contain lead or be lead-free. There are few studies that have examined the toxic effects of inhaling benzene fumes on experimental animals. This study aimed to investigate the sub-acute toxicity of inhaling benzene vapor in experimental rats. The rats were exposed to benzene vapors for 1, 2, and 4 hours daily for 5 days per week. The experiment lasted for 3 weeks. Benzene vapor inhalation for 4 hours per day resulted in 13.3% mortality in the last week of the study. The study also showed the presence of behavioral changes in rats, as demonstrated by low values of the head poking test at all times of exposure to benzene. Inhaling benzene vapors resulted in a statistical decrease in the rat's red blood cell number, weight gain, the level of dopamine in the serum, the hemoglobin concentration, as well as the high-density lipoproteins cholesterol (HDL-C). On the other hand, benzene vapor inhalation resulted in a noticeable increase in the number of white blood cells, platelets, liver enzymes (AST & ALT), kidney function (urea, uric acid, & creatinine), and also lipid profile (total cholesterol, triglyceride & low-density lipoprotein cholesterol (LDL- C)) in the serum. The study also reported pathological changes in the kidneys of rats when exposed to benzene vapor. The study confirmed the benzene toxicity, which could adversely affect the nervous system, blood picture, liver and kidney functions, as well as the image of lipids in the blood.


How to cite this article
and Maha Ibrahim A A A. Neurological and Biological Toxicity of Subchronic Exposure to Inhaled Benzene in Male Rats. J Biochem Technol 2020;11(2):52-9
INDEXING
+ Pubmed Central, DOAJ, SCIRUS, BiologyBrowser, Chemical Abstracts, CABI, Intute catalogue, Science Central, EBSCOhost databases, Google Scholars, Genamics JournalSeek, Open J gate, Ulrich's, ResearchGate and many more.

J BIOCHEM TECH
J BIOCHEM TECH
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

Publish with us

Call for papers

Issue 3 Volume 11 - 2020

Publishing steps

1.Prepare
your paper
2.Submit
and revise
3.Track
your research
4.Share
and promote
This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative