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2021 Volume 12 Issue 3

Jatropha curcas Leaf Extract and Fractions Attenuate Hyperglycemia, Tissue Oxidation, and Kidney Dysfunction in Diabetic Rats


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Abstract

This research studied the effect of extract and fractions of Jatropha curcas leaf, on serum glucose, kidney function and tissue oxidative stress indices of diabetic Wistar rats. The design comprised of 6 groups (n=6) treated: Groups I (NC) and II (DC), the normal and diabetic controls, respectively, received 3% tween-80 and groups III - VI (diabetic rats) received 500 mg/kg bodyweight of Metformin (MF) and 200 mg/kg bodyweight each of ethanol extract (ELE), residue (ERF) and n-hexane (NHF) fractions, respectively. Thereafter, blood, kidney, and liver samples were obtained and used for biochemical analyses. The 14-day oral administration of ELE, ERF, NHF, and metformin lowered serum glucose relative to the DC (P<0.05), with ERF and NHF exerting a stronger glucose-lowering action than ELE (P<0.05). The bodyweights, as well as absolute and relative organ weights, were not significantly affected. The observed diabetes-induced hyponatremia, hypochloraemia, and hyperkalemia were ameliorated upon the intervention of ELE, ERF, NHF, and MF, which lowered K+ vs DC (P<0.05); ELE, NHF, and MF heightened Cl- vs DC (P<0.05). However, only MF improved the lowered Na+ level. The diabetes-induced oxidative stress was also modulated: increased CAT, SOD, and GSH, with a concomitant decrease in MDA in both liver and kidneys relative to the DC (P<0.05). Besides, validation of the antidiabetic claim, J. curcas leaf modulates hyperglycemia-induced oxidation stress and assuage some worrisome features of kidney dysfunction in diabetes, including hyponatremia and hyperkalemia.


How to cite this article
Vancouver
Asuk AA, Atangwho IJ, Ugwu MN, Ati BU. Jatropha curcas Leaf Extract and Fractions Attenuate Hyperglycemia, Tissue Oxidation, and Kidney Dysfunction in Diabetic Rats. J Biochem Technol. 2021;12(3):84-90. https://doi.org/10.51847/3ChBg8qAJJ
APA
Asuk, A. A., Atangwho, I. J., Ugwu, M. N., & Ati, B. U. (2021). Jatropha curcas Leaf Extract and Fractions Attenuate Hyperglycemia, Tissue Oxidation, and Kidney Dysfunction in Diabetic Rats. Journal of Biochemical Technology, 12(3), 84-90. https://doi.org/10.51847/3ChBg8qAJJ
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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a double-blind peer reviewed International Journal published by the Deniz Publication on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal of Biochemical Technology provides a publication on all aspects of biochemistry, biotechnology & bioinformatics and applications in biology and medicine. Areas of high interest cover new advances in enzymatic and protein mechanisms; applied molecular genetics and biotechnology; computational biology, genomics and proteomics; metabolic & tissue engineering; medical, environmental, Pharmacy and pharmaceutical chemistry, food and agro-biotechnology.

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative