%0 Journal Article
%T Jatropha curcas Leaf Extract and Fractions Attenuate Hyperglycemia, Tissue Oxidation, and Kidney Dysfunction in Diabetic Rats
%A Atamgba Agbor Asuk
%A Item Justin Atangwho
%A Melvin Nnaemeka Ugwu
%A Boniface Unimke Ati
%J Journal of Biochemical Technology
%@ 0974-2328
%D 2021
%V 12
%N 3
%R 10.51847/3ChBg8qAJJ
%P 84-90
%X This research studied the effect of extract and fractions of Jatropha curcas leaf, on serum glucose, kidney function and tissue oxidative stress indices of diabetic Wistar rats. The design comprised of 6 groups (n=6) treated: Groups I (NC) and II (DC), the normal and diabetic controls, respectively, received 3% tween-80 and groups III - VI (diabetic rats) received 500 mg/kg bodyweight of Metformin (MF) and 200 mg/kg bodyweight each of ethanol extract (ELE), residue (ERF) and n-hexane (NHF) fractions, respectively. Thereafter, blood, kidney, and liver samples were obtained and used for biochemical analyses. The 14-day oral administration of ELE, ERF, NHF, and metformin lowered serum glucose relative to the DC (P
%U https://jbiochemtech.com/article/jatropha-curcas-leaf-extract-and-fractions-attenuate-hyperglycemia-tissue-oxidation-and-kidney-dys-rdc3lewmbxylzwf