This study presents the results of the development and comprehensive evaluation of a novel adaptogenic herbal preparation "Ginskhizin," based on a combination of standardized extracts of Panax ginseng C.A. Mey. and Schisandra chinensis (Turcz.) Baill. The experimental work was conducted on a laboratory rat model using modern pharmacological, biochemical, and toxicological methods. The results demonstrate pronounced adaptogenic effects of the preparation, manifested in a dose-dependent increase in motor activity by 28-42% and improvement in endurance parameters by 25-39% compared to the control group. A distinctive feature of "Ginskhizin" is its favorable impact on the cardiovascular system—a moderate increase in systolic blood pressure by 14±3 mmHg was not accompanied by tachycardia. Biochemical studies revealed the preparation's multifaceted action, including a 25% reduction in cortisol levels, a 20-30% increase in antioxidant enzyme activity, and a decrease in oxidative stress markers. Toxicological evaluation confirmed the high safety profile of the preparation, with an LD50 exceeding 2000 mg/kg, and only minor changes in liver functional indicators observed during prolonged use. The obtained data indicate the potential of "Ginskhizin" as a safe and effective alternative to synthetic stimulants for the management of asthenic conditions, hypotension, and increased physical and mental stress. The developed preparation combines rapid tonic effects with prolonged adaptogenic action, offering new possibilities for treating conditions associated with reduced performance.
