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2023 Volume 14 Issue 3

Colorectal Cancer Biomarkers Discovery Approach: A Proteomic and Genomic Perspective


Abstract

Colorectal cancer is a major global health concern, necessitating the identification of biomarkers for early detection, prognosis, and therapeutic targeting. In recent years, proteomic and genomic approaches have revolutionized cancer research, providing valuable insights into the molecular mechanisms underlying CRC. Epidemiological and clinical studies point to a connection between inflammation and development of cancer. Incidences of (CRC) have increased globally during the past decade.  In this review, we will discuss the biomarker discovery approach for CRC, which involves a combination of proteomic and genomic perspectives. There are numerous promising biomarkers that must improve life expectancy or quality of life to be evaluated for use in clinical practice. We will cover the important steps such as sample collection, protein extraction, separation, mass spectrometry (MS) analysis, genomic profiling, data analysis, validation, and functional characterization. By utilizing both proteomics and genomics, researchers can identify potential biomarkers for CRC, leading to better diagnostics and personalized treatment options.


How to cite this article
Vancouver
Al-Zahrani MH. Colorectal Cancer Biomarkers Discovery Approach: A Proteomic and Genomic Perspective. J Biochem Technol. 2023;14(3):6-12. https://doi.org/10.51847/gVy1I4x9BU
APA
Al-Zahrani, M. H. (2023). Colorectal Cancer Biomarkers Discovery Approach: A Proteomic and Genomic Perspective. Journal of Biochemical Technology, 14(3), 6-12. https://doi.org/10.51847/gVy1I4x9BU
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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a double-blind peer reviewed International Journal published by the Deniz Publication on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal of Biochemical Technology provides a publication on all aspects of biochemistry, biotechnology & bioinformatics and applications in biology and medicine. Areas of high interest cover new advances in enzymatic and protein mechanisms; applied molecular genetics and biotechnology; computational biology, genomics and proteomics; metabolic & tissue engineering; medical, environmental, Pharmacy and pharmaceutical chemistry, food and agro-biotechnology.

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative