TY  - JOUR
T1  - Colorectal Cancer Biomarkers Discovery Approach: A Proteomic and Genomic Perspective
A1  - Maryam Hassan Al-Zahrani
JF  - Journal of Biochemical Technology
JO  - J Biochem Technol
SN  - 0974-2328
Y1  - 2023
VL  - 14
IS  - 3
DO  - 10.51847/gVy1I4x9BU
SP  - 6
EP  - 12
N2  - Colorectal cancer is a major global health concern, necessitating the identification of biomarkers for early detection, prognosis, and therapeutic targeting. In recent years, proteomic and genomic approaches have revolutionized cancer research, providing valuable insights into the molecular mechanisms underlying CRC. Epidemiological and clinical studies point to a connection between inflammation and development of cancer. Incidences of (CRC) have increased globally during the past decade.  In this review, we will discuss the biomarker discovery approach for CRC, which involves a combination of proteomic and genomic perspectives. There are numerous promising biomarkers that must improve life expectancy or quality of life to be evaluated for use in clinical practice. We will cover the important steps such as sample collection, protein extraction, separation, mass spectrometry (MS) analysis, genomic profiling, data analysis, validation, and functional characterization. By utilizing both proteomics and genomics, researchers can identify potential biomarkers for CRC, leading to better diagnostics and personalized treatment options.
UR  - https://jbiochemtech.com/article/colorectal-cancer-biomarkers-discovery-approach-a-proteomic-and-genomic-perspective-gfdr7gxfaxts7vv
ER  -