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2022 Volume 13 Issue 1

Antioxidant and Antidiabetic Effect of Biosynthesis Zinc Nanoparticles by Using Polyherbal Aqueous Extract in Wistar Rats


Derouiche Samir, Benmoussa Ouissam, Djouadi Anfal
Abstract

The goal of this study was to see how ZnNPs (a green synthesis formulation) affected the physiological, biochemical, and oxidative stress changes generated by experimental diabetes in rats. Twenty female albino Wistar rats were randomly separated into four groups (n=5): control, zinc nanoparticles, diabetic rats, and diabetic rats treated with zinc nanoparticles. Rats were given all types of treatments orally for 21 days. Alloxan (150mg/kg) was used to make rats diabetic. Various parameters were calculated, including biochemical, hematological, and oxidative stress markers. Histopathological lesions of pancreas tissues were noticed. Characterizations of nanoparticles were analyzed using standard technics. UV-Vis Spectroscopy revealed that ZnNPs exhibit a peak at 230 nm, and SEM indicated that the produced ZnNPs are a smaller size than 21.5 nm. The FTIR spectra revealed a peak in the range of 400-700 cm-1. In vivo results revealed a change in the diabetic group's lipid profile and metabolic markers. While the liver, kidneys, and pancreas antioxidant defense systems were harmed, by increasing MDA levels and GSH levels and SOD activity are declining compared to control. Furthermore, hematological measurements demonstrated that diabetes reduced RBC, MCV, and HCT levels significantly (P<0.01). When diabetic rats' pancreas tissues were compared to control rats', histopathological examination revealed a difference. On the other hand, treating diabetic rats with ZnNPs), improved and corrected partially of the prior parameters. Finally, the utilization of ZnNPs synthesized by polyherbal extract appears to be the most important limiting factor in diabetes development and consequences.


How to cite this article
Vancouver
Samir D, Ouissam B, Anfal D. Antioxidant and Antidiabetic Effect of Biosynthesis Zinc Nanoparticles by Using Polyherbal Aqueous Extract in Wistar Rats. J Biochem Technol. 2022;13(1):72-80. https://doi.org/10.51847/h9WwU5fRNa
APA
Samir, D., Ouissam, B., & Anfal, D. (2022). Antioxidant and Antidiabetic Effect of Biosynthesis Zinc Nanoparticles by Using Polyherbal Aqueous Extract in Wistar Rats. Journal Of Biochemical Technology, 13(1),72-80. https://doi.org/10.51847/h9WwU5fRNa
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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative