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2020 Volume 11 Issue 4

The Histological Structure of Pig Organs and Tissues during the Experimental Use of the Triazavirin Antiviral Drug


Tatiana Ivanovna Reshetnikova, Alexander Sergeyevich Zenkin, Tatyana Georgievna Krylova
Abstract

The authors have set the goal to experimentally study the effect of the Triazavirin antiviral drug on pigs, as well as the histological structure, the state, and abnormalities in several organs and tissues after the administration of the Triazavirin antiviral drug. For the experiment, an experimental group of 25 piglets has been formed. The animals have been kept in the same zoohygienic conditions, have had the same diet according to the age and the feeding technology. The piglets in the experimental group with symptoms of respiratory system impairment have received the Triazavirin antiviral drug as experimental etiological therapy. The drug has been given to the experimental animals with drinking in the form of an aqueous solution. After the slaughtering of the experimental animals at a meat processing factory, pieces of organs have been collected for histological examination — the trachea, the bronchi of the lungs and adjacent lymph nodes, the liver, the kidneys, the spleen, the heart, and the ovaries. During the experiment and administration of the Triazavirin antiviral drug in the indicated doses, no lethality has been observed in the experimental piglets. In the experimental group, the piglets' state has improved, the temperature has returned to normal, the appetite has improved, and there have been no clinical signs of respiratory impairment. As a result of the experiment with the piglets during the histological studies of several organs, no significant deviations from the norm have been revealed in their structure. The organs of the respiratory system have stabilized and have had a morpho-histological structure close to normal, which is a positive result of the experiment. Analyzing the data of the histological studies, it may be concluded that the Triazavirin antiviral drug does not cause changes in the morphology of the tissues of the studied internal organs. Based on the above, the authors recommend using the Triazavirin antiviral drug as part of comprehensive etiological therapy for the treatment of the respiratory system in pigs, including the treatment of viral diseases.


How to cite this article
Reshetnikova T I, Zenkin A S, Krylova T G. The Histological Structure of Pig Organs and Tissues during the Experimental Use of the Triazavirin Antiviral Drug. J Biochem Technol 2020;11(4):1-7
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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative