The Biochemical Effects of Lead Concentration on Oxidative Stress Parameters in Workers

Hamzeh Salehzadeh , Mehrzad Ebrahemzadih , Mohammad Reza Nourani , Fatemeh Mohebbinia and Ramezan Ali Taheri

Abstract

The goal of this study was to determine the blood lead concentration in various occupational workers in Sanandaj and its effects on oxidative stress parameters and other blood parameters. This descriptive-analytic study was carried out in Sanandaj, Iran. A total of 278 subjects were selected as the sample size for this study, of which 64 did not have exposure to theoccupational lead, and 214 had the occupational exposure tolead. The blood lead levels were measured by the atomic absorption spectrophotometer apparatus AA6800. Oxidative stress parameters and other blood parameters were measured by special devices. There was a significant positive relationship between the blood lead concentration and the oxidative stress parameters including lipid peroxidation, malondialdehyde, glutathione, antioxidant serum, and catalase. There was a significant negative relationship between the blood lead concentration and hematological parameters. Also, there was a significant positive relationship between the blood lead level and the lead concentration in the air.



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