Study of the Thermodynamic Parameters for Interaction of Ciprofloxacin Antibiotic with Bulk and Nanocopper Sulfate

Elsayed M. AbouElleef and Saleh D. Mekkey

Abstract

The association parameters of both bulk and nano-CuSO₄ salts in (EtOH-H₂O) mixed solvents were estimated at room temperature (293.15K) using conductivity method by applying Fuoss-Shedlovsky calculation. The association parameters of nano-CuSO4 was greater than bulk CuSO₄ salt. The interaction between the cation (Cu²+) with ligand (ciprofloxacin, CFL) in (EtOH-H₂O) mixed solvents at room temperature (293.15K) was determined by the conduct metric method. The formation Gibbs free energies change (∆Gf) and transfer Gibbs free energies change (∆Gt) were increased in negative signs with increasing in EtOH content in the binary solvent. Two stoichiometric complexes 1:2 and 1:1 (M:L) are formed and the formation constant and Gibbs free energy of the formed complexes follow the order: Kf (1:1) > Kf (1:2) and ∆Gf (1:1) > ∆Gf (1:2) for (M:L) ( in negative values), which indicate more favorable formation of (1:1) complex compared with (1:2) complex. Also there are a decrease in values of Kf and ∆Gf in case of using nano-CuSO4 than that of using bulk-CuSO₄ but in small difference due to the more solvation effect in case of using nanoparticles



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