A simple, rapid and accurate HPLC method was developed and assessed for the simultaneous estimation of Chlorpromazine hydrochloride and Carvedilol in its bulk and Pharmaceutical tablets. The separation was obtained by using C18 ec (250 × 4.6 mm, 5μm) column with a mobile phase composing of acetonitrile: deionized water (50: 50 v/v, pH adjusted to 3.6 ± 0.03 with acetic acid) at flow rate of 1.5 mL.min-1. The detection was carried out at 237nm, the retention time of CLO, and CARs were 1.56 and 3.84 min; respectively. The linearity range of 2-150 μg/mL and 1-150 μg/mL were selected for CLO and CAR; respectively. The correlation coefficients were found to be 0.9995 and 0.9999, and the limits of detection were found to be 0.6259μg/mL and 0.9365μg/mL for CLO and CAR; respectively. All the validation parameters were found to be within the acceptance limit. The developed HPLC method can be successfully used for the quantitative estimation of the two cited drugs in their formulation.