Background: Prosthodontics is known to be the science of skills and crafting art. It is an advanced branch of dentistry that involves more supportive biomechanical or absolute surgical interventions regarding external and internal structural restoration, either by maxillofacial rehabilitation prosthetics, or teeth implants that can be subdivided into removable or fixed prostheses. Objectives: This review highlights and analyzes different aspects of prosthodontics embracing the indications, divisions and branches, approach, and decision making while following up on the prognosis and sudden complications to assist professional practitioners in managing prosthodontic procedures. Methodology: This literature was conducted and assessed by (Google Scholar, PubMed) database research, and used the following terms within abstract or title ((“Prosthodontics"[Mesh] AND “Indications "[Mesh] AND “Dentures” Mesh] AND “Prognosis"[Mesh]AND “Complications”[Mesh] AND “Removable"[Mesh]AND “Fixed”[Mesh] “Prostheses”[Mesh] AND “Maxillofacial"[Mesh]AND “Implants”[Mesh])). Conclusion: Despite the limited and sufficient knowledge and background regarding prosthodontics It is essential to understand that the key to outstanding tooth restoration and masticatory function is based on fulfilling prosthetic treatment requirements and a better approach in decision making in prosthetic interventions.