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2020 Volume 11 Issue 2

Phosphatidylserine as Red Cell Eryptosis Marker Consolidating Phagocytotic Clearance


Hisham Ali Waggiallah
Abstract

Erythrocyte damage such as osmotic shock, oxidative stress, or energy depletion promotes the generation of prostaglandin E2 by activating cyclooxygenase, which triggers a permeable Ca+2 cation channel. Ca+2 further promotes the transfer of Phosphatidylserine from the cell membrane inside to the outer by a scramblase. Macrophages recognize phosphatidylserine at the surface of the erythrocyte which engulfs and degrade the affected cells. Also, the revealing phosphatidylserine red cell may bind to the vascular wall, interfering with microvessels.  Erythrocyte shrinkage and exposure to phosphatidylserine ("eryptosis") mimic apoptosis characteristics in nucleated cells which, however, involve many processes lacking in red cells. Several conditions cause premature eryptosis, thereby favoring anemia progress. Moreover, eryptosis may be a faulty mechanism for erythrocytes to avoid hemolysis. Phosphatidylserine has been considered the key marker of eryptosis and serves as the primary booster in the reticuloendothelial system to eliminate red blood cells by the macrophage.


How to cite this article
Waggiallah H A. Phosphatidylserine as Red Cell Eryptosis Marker Consolidating Phagocytotic Clearance. J Biochem Technol 2020;11(2):77-81
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J BIOCHEM TECH
J BIOCHEM TECH
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative