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2014 Volume 5 Issue 3

Peptide ABMOK1 designed from extracellular polymer substance (EPS) of Nitzschia sp. (Bacillariophyceae): Disruption of the membrane completeness of Escherichia coli


Abstract
Peptide ABMOK1 is composed of 12 amino acid and can interact with the membrane of Escherichia coli. We have carried out isolation, sequencing, prediction, and synthesis of ABMOK1, which is a peptide of membrane activity. LC-MS/MS mapped the ABMOK1 primary structure, CGYCGACVGVCK; SOPMA predicted secondary structure and random coil, while CAMP was used to predict the antimicrobial probability. LC-MS/MS, SOPMA, and CAMP from this study provide the foundation for comprehensive functional and structural characterization of the peptide ABMOK1. That is first time public peptide from Nitzschia sp. ABMOK1 was interacted with membrane of Escherichia coli with the features of an unstable membrane. The results may help point to new directions for future peptide research with benthic diatoms.

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J BIOCHEM TECH
J BIOCHEM TECH
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative