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2016 Volume 7 Issue 1

Modulatory Effects of Carica papaya (Linn.) on Electron Beam Radiation Induced Hematological Suppression and Biochemical Alterations in Swiss Albino Mice


Abstract
The present study was undertaken to evaluate the leaf extracts of Carica papaya (Linn.) on hematologic and biochemical changes occurring due to irradiation of mice to sub-lethal doses of Electron Beam Radiation (EBR).The immunomodulatory response of C. papaya (Linn.) extract to the radiological effects by determining the levels of interleukin-6. The serum total antioxidants, lipid peroxidation and the biochemical changes in liver and kidney function were assessed. Reduction in the hematological parameters like hemoglobin, RBC, WBC and platelets were seen in the irradiated groups compared to the control group. The elevated serum malondialdehyde levels indicate increased lipid peroxidation and reduced glutathione levels and total antioxidant capacity suggest prominent oxidative stress in the irradiated groups. C. papaya (Linn.) (pre-treatment + radiation) treated groups have shown significant improvements in the hematological parameters. Reduction in the malondialdehyde levels and increased reduced glutathione levels indicate amelioration of the oxidative stress. There is decrease in the cytogenetic damages in the C.papaya (Linn.) (pre-treatment + radiation) treated groups compared to the radiation control. Significant changes were seen in the interleukin-6 levels of C. papaya (Linn.) (pre-treatment + radiation) treated groups indicate enhanced immune response compared to the irradiation control groups. The results indicate that the C. papaya (Linn.) aqueous extracts play a protective role in radiation induced hematological and antioxidant suppression. Also it enhances membrane stabilization and reduces cytogenetic damages.

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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative