Microbial hydroxylation of dydrogesterone by Rhizopus stolonifer


Abstract

Microbial hydroxylation of dydrogesterone (9b,10a-pregna-4,6-diene-3,20-dione) (1) on fermentation with Rhizopus stolonifer afforded a new metabolite, 9b,12b-dihydroxy-9b,10a-pregna-4,6-diene-3,20-dione (2). Its structure was deduced on the basis of modern spectroscopic techniques.



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