Safflower was introduced into the Central region of the Russian Federation. The results of many years of research have a fundamental and applied significance. Vegetation period from germination to maturity in the years with different meteorological conditions is 94-114 days. The weight of 1000 seeds is 48-51 g. Productivity in contrast zone is 0.7-1.7 t/ha. Safflower seeds contain 30.2-30.9% of fat, the yield of oil is 240 liters kg/ha (in unrefined seeds). From diseases during the wet years of ripening, the safflower culture is affected by enzymatic mycosis seed depletion (EMIS). The enzyme stage of EMIS opens the gate from the seed formation phase to the introduction of the phytopathogens of the genera Alternaria, Fusarium, Botrytis, and Sclerotinia. The results of the research showed the suitability of safflower cultivation Krasa Stupinskaya in the Central Region of the Russian Federation for obtaining seeds and oil.